Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Serum sodium level is a major predictor of a poor prognosis for heart failure patients

09.03.2005


Findings presented at ACC Scientific Sessions show improving serum sodium levels may improve outcomes



Research presented on Monday at the American College of Cardiology’s Scientific Sessions in Orlando pinpoints a major marker of a poor prognosis for heart failure, hyponatremia, or a lower than normal concentration of serum or blood sodium. Researchers found that hyponatremia, which is found in almost a quarter of patients with severe heart failure, doubled death rates within 60 days of hospital discharge. Serum sodium levels are easily measured through routine blood tests.

"Even a minor decrease in a person’s serum sodium level – levels that are now dismissed by physicians – had a major impact on mortality of heart failure patients," says Mihai Gheorghiade, MD, associate chief, Division of Cardiology, Northwestern Memorial Hospital and Northwestern University Feinberg School of Medicine, and lead presenter of the findings from the ESCAPE trial during a poster session on Monday.


Heart failure is a major health threat in this country, resulting in 1 million hospital admissions each year. "These findings illustrate that not all heart failure is created equally – heart failure accompanied with hyponatremia is especially dangerous. Levels of serum sodium may prove a useful and easily accessible risk assessment tool in the clinical management of patients hospitalized for heart failure," says Dr. Gheorghiade.

The good news is that a separate study presented Monday by Dr. Gheorghiade showed that improvement in sodium serum levels during hospitalization was associated with improved outcomes. In the ACTIV trial, patients with a serum sodiuim improvement at hospital discharge had a 15.6 percent mortality rate at 60 days post discharge, compared with a 30.4 percent mortality rate in those showing no improvement. "Currently, the medical community is not paying much attention to serum sodium levels in heart failure patients. However, serum sodium appears to be a modifiable target that can be treated," says Dr. Gheorghiade.

A paper authored by Dr. Gheorghiade and published in JAMA in April of 2004 found that the medication tolvaptan was a promising addition to standard therapy for patients hospitalized with heart failure. In addition to reducing fluid buildup and decreasing body weight, tolvaptan improved serum sodium levels in patients with hyponatremia. "This is important because previously, we have not had very effective therapies for treating hyponatremia in patients with heart failure. Now, we think it can be treated, and we have an understanding that treating it can make a huge difference for the patient," says Dr. Gheorghiade.

Sodium is an electrolyte that helps with nerve and muscle function, and also helps to maintain blood pressure. Hyponatremia most commonly occurs in people whose kidneys do not function properly, as well as in those with heart failure, cirrhosis of the liver, and Addison’s disease. Sodium must be maintained at a specific concentration in the blood and the fluid surrounding the body’s cells for the body to function properly.

Amanda Widtfeldt | EurekAlert!
Further information:
http://www.nmh.org

More articles from Health and Medicine:

nachricht Second cause of hidden hearing loss identified
20.02.2017 | Michigan Medicine - University of Michigan

nachricht Prospect for more effective treatment of nerve pain
20.02.2017 | Universität Zürich

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Start codons in DNA may be more numerous than previously thought

21.02.2017 | Life Sciences

An alternative to opioids? Compound from marine snail is potent pain reliever

21.02.2017 | Life Sciences

Warming ponds could accelerate climate change

21.02.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>