Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Proteins found in urine of pregnant women could help diagnose preeclampsia

08.03.2005


Researchers at Yale School of Medicine have found that specific substances in the urine of pregnant women could serve as a screening/diagnostic tool for preeclampsia (hypertension and proteinuria during pregnancy). The study is published in March issue of American Journal of Obstetrics and Gynecology.



"Preeclampsia is one of the most common causes of maternal mortality in the United States, but establishing a correct diagnosis can be very difficult, especially in women with hypertension prior to pregnancy," said lead author Catalin Buhimschi, M.D., assistant professor in the Department of Obstetrics, Gynecology and Reproductive Sciences at Yale School of Medicine.

Buhimschi and his colleagues developed a new algorithm to calculate the ratio for the presence or absence of three specific proteins that are normally secreted by human placenta. They examined samples of urine and blood from 132 women, some of whom had other causes of hypertension. The ratio between two of the proteins correctly identified all the women who had severe preeclampsia.


"It will take several years to develop a new diagnostic test," said Buhimschi. "Many factors are present in the serum and blood, but only the relationship between them has diagnostic significance."

The proteins studied were vascular endothelial growth factor (VEGF), placental growth factor (PlGF), and their soluble VEGF receptor (sFlt–1). The ratio of sFlt–1 and PlGF had a high sensitivity (88 percent) and specificity (100 percent) for identifying severe preeclampsia, and was more accurate than proteinuria alone.

Buhimschi said current tests such as liver function, proteinuria and platelet count are neither accurate nor sensitive, and results can be confusing, placing women at risk of giving birth prematurely. The current treatment is delivery of the fetus regardless of gestational age. These results provide scientists with a better understanding of the mechanisms of preeclampsia.

Co–authors are Errol R. Norwitz, M.D., Edmund Funai, M.D., Susan Richman, M.D., Seth Guller, M.D., Charles J. Lockwood, M.D., and Irina A. Buhimschi, M.D.

Karen N. Peart | EurekAlert!
Further information:
http://www.yale.edu

More articles from Health and Medicine:

nachricht Plasmonic biosensors enable development of new easy-to-use health tests
14.12.2017 | Aalto University

nachricht ASU scientists develop new, rapid pipeline for antimicrobials
14.12.2017 | Arizona State University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

Im Focus: Successful Mechanical Testing of Nanowires

With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong

Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Plasmonic biosensors enable development of new easy-to-use health tests

14.12.2017 | Health and Medicine

New type of smart windows use liquid to switch from clear to reflective

14.12.2017 | Physics and Astronomy

BigH1 -- The key histone for male fertility

14.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>