Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

MRI Better Than Current Standard of Practice In Assessing Neoadjuvant Chemotherapy in Breast Cancer Patients

04.03.2005


More breast cancer patients with large palpable tumors are now undergoing chemotherapy before surgery in an effort to reduce the size of their tumor, and MRI is the best way to predict if the chemotherapy is working, preliminary results of a study show. If the chemotherapy is successful, then the woman may be able to undergo breast-conservation surgery rather than a mastectomy.



Currently, it is standard practice for the physician to do a breast examination to non-invasively assess whether the chemotherapy was effective, said Eren Yeh, MD, an instructor of radiology at Massachusetts General Hospital in Boston, and the lead author of the study. “Before we began the study, we weren’t sure if breast tumors would enhance with the MR contrast agent gadolinium and therefore be visible after chemotherapy. Our study found that MRI is not perfect, but it’s better than what’s been used as the gold standard in the past,” she said.

For the study, 31 patients prospectively underwent clinical examination, mammography, sonography and an MRI examination before, then following, chemotherapy. The results of these tests were then compared to the pathology results following surgery. MRI was right (when compared to pathology results) 71% of the time. It overestimated the amount of residual tumor in 6% and underestimated the amount of residual tumor in 23% of patients.


Sonography, on the other hand, was right only 35% of the time, overestimating the amount of tumor after chemotherapy in 13% and underestimating the amount of tumor in 52% of the cases. Clinical examination agreed with pathology in 19% of the cases, underestimating in 55% and overestimating the amount of disease in 26% of the cases; mammography was right in 26% of the cases, underestimating the amount of disease in 52% and overestimating in 23% of the cases.

In addition to being more accurate, MRI detected two additional lesions that were not seen on the other imaging methods, and these findings altered the way the patients were treated, said Dr. Yeh. "In the future, we hope to use MRI earlier in the chemotherapy treatment to determine if the toxic therapy is reducing the tumor size. If it’s not working, we can perhaps change the drug that’s being used—in fact tailor treatment for each patient,” she said.

The study appears in the March 2005 issue of the American Journal of Roentgenology.

Jason Ocker | EurekAlert!
Further information:
http://www.arrs.org

More articles from Health and Medicine:

nachricht Minimising risks of transplants
22.02.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

nachricht FAU researchers demonstrate that an oxygen sensor in the body reduces inflammation
22.02.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Developing reliable quantum computers

International research team makes important step on the path to solving certification problems

Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Stiffness matters

22.02.2018 | Life Sciences

Magnetic field traces gas and dust swirling around supermassive black hole

22.02.2018 | Physics and Astronomy

First evidence of surprising ocean warming around Galápagos corals

22.02.2018 | Earth Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>