University of California researchers have created a mathematical model describing the electrical storm that rages during a brain seizure. They say the model, to be published in the March 22 print issue of the Journal of the Royal Society of London Interface, but available now to subscribers online, may eventually help neurologists better understand and treat epilepsy.
A lateral skull radiograph of an epilepsy patient with a series of electrodes implanted into his brain by Dr. Nicholas Barbaro at UCSF. The electrodes allowed neurologists to map the electrical activity produced during the patients seizures in preparation for brain surgery. The inset at right highlights the mathematical model of the electrical waves, which was compared with the actual readings from the two electrodes noted. (Image courtesy of UC Regents)
These waves compare observed electrocorticogram (ECoG) readings taken from an epilepsy patient (upper pair of curves) with simulated data from a mathematical model created by UC researchers (lower pair). Within the pairs, the upper ECoG trace was recorded during normal brain activity, while the lower ECoG trace was recorded during a seizure. The results of the simulated data are very similar to the observed readings. (Image by Mark Kramer, courtesy of UC Regents)
"Were trying to get to the underlying state of the brain that leads to these seizures," said Mark Kramer, a Ph.D. student in UC Berkeleys Applied Science and Technology Program and lead author of the paper. "Our hope is that the model can highlight potential areas where a seizure can be stopped."
There are several possible causes for the abnormal signaling in epilepsy, including illness, injury, abnormal brain development and an imbalance of the chemical neurotransmitters needed to convey messages in the brain. Some seizures begin in a very specific area of the brain called the "seizure focus" before spreading out, and others, particularly ones linked to genetic causes, appear to start simultaneously in various parts of the brain.
Sarah Yang | EurekAlert!
Correct connections are crucial
26.06.2017 | Charité - Universitätsmedizin Berlin
One gene closer to regenerative therapy for muscular disorders
01.06.2017 | Cincinnati Children's Hospital Medical Center
An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.
Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...
Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.
Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...
Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.
As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...
Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.
With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...
Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine
Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...
19.06.2017 | Event News
13.06.2017 | Event News
13.06.2017 | Event News
26.06.2017 | Life Sciences
26.06.2017 | Physics and Astronomy
26.06.2017 | Information Technology