A substance similar to a drug used in the treatment of Parkinson’s disease blocks the stimulating effects of cocaine and could potentially be used to develop drug therapy for cocaine abuse, new research shows.
In an article published in the February 23, 2005, issue of The Journal of Neuroscience, Jonathan Katz and his colleagues at the National Institute on Drug Abuse (NIDA) report the results of experiments showing that mice treated with a substance similar to the drug benztropine did not show any of the typical hyperactive behavior when later injected with cocaine. This effect wore off after a day.
Cocaine produces intense feelings of euphoria by increasing the amount of dopamine that is sent from one neuron to another within the brain reward system. Dopamine signals pleasure and reward by binding to receptors on the receiving neurons, after which it is reabsorbed for later use by a protein that transports it back into the sending neuron. But cocaine blocks the mechanism that transports dopamine, causing it to build up and send an unceasing message of pleasure – the cocaine high.
Elissa Petruzzi | EurekAlert!
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MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
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