Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New point system enhances prognosis for GIST patients

07.02.2005


A research team at the Sahlgrenska Academy at Göteborg University in Sweden has developed a point system for calculating risk that will help physicians determine prognoses, survival rates, and the best methods of treatment for patients suffering from GIST tumors. The findings are being published in the prestigious medical journal Cancer.



GIST is a soft tissue tumor that occurs in the abdomen but differs from gastro-intestinal cancer. Nearly two hundred Swedes are affected every year. Long-term survival rates have been low. GIST tumors can grow very large and occupy a major section of the abdomen. Some tumors weigh as much as five kilos. For many years the only method of treatment was surgery, but over the last four years it is has been possible to combine surgery with new medicinal treatment in the form of the medicine Imatinib. The medicine is administered to inhibit the growth of the tumor and to prevent the emergence of new tumors and metastases.

Of all GIST patients, 44 percent develop highly aggressive tumors that in many cases are fatal. These patients should receive priority for medicinal treatment. The new medicine Imatinib is the first drug that effectively treats patients with malignant GIST.


“GIST tumors have been under-diagnosed. Therefore there is a great risk that patients will not receive optimal treatment. The development of Imatinib offers the first effective medicinal treatment of aggressive GIST. Therefore it has become absolutely essential for pathologists, surgeons, and oncologists to be able to diagnose this tumor correctly and to determine just how aggressive the tumor is in order to provide the best possible care,” says Professor Lars-Gunnar Kindblom, who directed the present study together with Professor Jeanne Meis-Kindblom and Associate Professor Bengt Nilsson.

On the basis of a unique study of all GIST cases in Western Sweden between the years 1983 and 2000, Lars-Gunnar Kindblom’s research team developed a system of points. Using this system it is possible to determine a patient’s prognosis in terms of both survival and the risk of developing new tumors. The system is based how large the tumor is and how quickly it is growing, which is determined by analyzing tissue samples.

The scientists divided the GIST patients into four groups­-extremely low risk, low risk, moderate risk, and high risk­-on the basis of the size of the tumor and an index that calculates how many cells are dividing. Of the 170 patients with GIST tumors classified as extremely low risk, low risk, and moderate risk, only one patient had a tumor that could not be operated on, and three patients had recurrent tumors. This can be compared with the 89 patients with high-risk tumors, among whom 36 had inoperable tumors and 35 developed new tumors after surgery. Among patients with high-risk tumors, 63 percent died as a result of their GIST tumors, as did 83 percent of those who had tumors that had already spread extensively. On the other hand, only one percent of the patients died of GIST among those with extremely low, low, and moderate risk levels.

Furthermore, the study shows that GIST is considerably more common that scientists previously believed. Worldwide, roughly 15 individuals per million develop the disease each year.

Ulrika Lundin | alfa
Further information:
http://www.sahlgrenska.gu.se/index_eng.jsp

More articles from Health and Medicine:

nachricht Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University

nachricht Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

From rocks in Colorado, evidence of a 'chaotic solar system'

23.02.2017 | Physics and Astronomy

'Quartz' crystals at the Earth's core power its magnetic field

23.02.2017 | Earth Sciences

Antimicrobial substances identified in Komodo dragon blood

23.02.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>