Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Rheumatoid arthritis patients have double the risk of heart failure

04.02.2005


Mayo Clinic researchers have found that rheumatoid arthritis patients have twice the risk of heart failure, or a weakening of the heart’s ability to pump blood, as those without rheumatoid arthritis, according to a new study to be published in the February edition of the journal Arthritis & Rheumatism. About one-third of the rheumatoid arthritis patients studied developed heart failure over 30 years of the disease.

"We decided to undertake this study because we knew that patients with rheumatoid arthritis die earlier than the general population, and mostly from heart disease," says Paulo Nicola, M.D., Mayo Clinic research fellow in the Department of Health Sciences Research and study author. "We thought heart failure could be a reason for early mortality in these patients. However, we were not expecting that the incidence of heart failure would be so high."

The study found that patients with rheumatoid arthritis are at an increased risk for heart failure soon after the onset of arthritis and that this elevated risk follows them throughout the course of the arthritis, a chronic disease. The researchers also found that the factors putting them at this increased risk for heart failure seem to be unrelated to heart attacks and to the traditional cardiovascular risk factors: diabetes; alcohol abuse; and elevated cholesterol, blood pressure and body mass index. The source of the increased risk remains a mystery, however.



"We expected heart attacks and traditional cardiac risk factors to contribute to the increased risk of heart failure in rheumatoid arthritis patients, but they did not," says Dr. Nicola. "This suggests another mechanism is at work. We suspect that it has something to do with the underlying inflammation that occurs in people with rheumatoid arthritis. Another possibility is that patients with rheumatoid arthritis are particularly vulnerable to develop heart disease through a mechanism that we don’t yet understand. These observations may also suggest the potential presence of a common susceptibility for developing rheumatoid arthritis or cardiac heart failure, or a shared origination of these diseases."

The study’s researchers also noted little difference between rates of heart failure in men and women with rheumatoid arthritis.

"This is quite different from what you’d find in the general population, where rates of heart failure are significantly higher among men than in women," says Dr. Nicola. "This suggests that whatever protects women from heart failure compared with men in the general population is not the same in patients with rheumatoid arthritis."

Heart failure is a serious disease, according to Dr. Nicola, causing a survival as short as most cancers. He indicates that in the general population, about one-half of heart failure patients die within three to five years.

At present, the study investigators cannot prescribe preventive measures for rheumatoid arthritis patients to take in order to avoid heart failure; they suggest that this is a subject for further study. The Mayo researchers also are conducting studies to find out which rheumatoid arthritis patients are at highest risk for heart failure and to identify whether arthritis medications are protective or contributors to heart failure.

In the meantime, Dr. Nicola says, "Patients with rheumatoid arthritis should be vigilant regarding reducing their traditional cardiac risk factors. Their physicians should have a high degree of suspicion of heart failure -- for example, they should be suspicious when rheumatoid arthritis patients relate that they are more tired than normal."

Lisa Lucier | EurekAlert!
Further information:
http://www.mayo.edu
http://www.rheumatology.org

More articles from Health and Medicine:

nachricht Observing the cell's protein factories during self-assembly
15.06.2018 | Charité - Universitätsmedizin Berlin

nachricht Scientists unravel molecular mechanisms of Parkinson's disease
13.06.2018 | The Francis Crick Institute

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

Im Focus: Photoexcited graphene puzzle solved

A boost for graphene-based light detectors

Light detection and control lies at the heart of many modern device applications, such as smartphone cameras. Using graphene as a light-sensitive material for...

Im Focus: Water is not the same as water

Water molecules exist in two different forms with almost identical physical properties. For the first time, researchers have succeeded in separating the two forms to show that they can exhibit different chemical reactivities. These results were reported by researchers from the University of Basel and their colleagues in Hamburg in the scientific journal Nature Communications.

From a chemical perspective, water is a molecule in which a single oxygen atom is linked to two hydrogen atoms. It is less well known that water exists in two...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Novel method for investigating pore geometry in rocks

18.06.2018 | Earth Sciences

Diamond watch components

18.06.2018 | Process Engineering

New type of photosynthesis discovered

18.06.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>