Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Tell me the size of your waist and I will tell you if you are in risk of prostate cancer

04.02.2005


Visceral fat, which is the fat found around our organs, is associated with increased danger of prostate cancer say scientists in today issue of Obesity Research.

For a long time abdominal obesity has been associated with an increase in cardiovascular diseases, diabetes, hypertension and some types of cancers. But until now, it has not been possible to establish a relationship between prostate cancer and weight, even if evidence supports the idea that environmental factors, such as western diet and life style, affect the incidence of the disease. A clear example of this relationship is the increase in prostate cancer among Japanese men emigrating to the United States from Japan (where the disease is still rare).

Pedro Von Hafe, Henrique Barros and colleagues from the Faculty of Medicine of Porto and the Hospital of São João, Porto, Portugal hypothesised that previous inconclusive results, found when studying the relationship between fat and prostate cancer, were due to the fact that the existence of different types of adipose tissue was never taken into account. And different types of fat tissue, because they possess different types of metabolism that produce different biochemical substances, affect the body in very different ways.



Adipose tissue in the human body comes in two types: subcutaneous fat which is located just below the skin, and visceral fat, which is located, unnoticed, below the muscles surrounding our vital organs and is much more harmful than subcutaneous adiposity. In fact, visceral fat is known, for example, to predispose to cardiovascular and metabolic problems although the mechanism(s) by which these complications appear is still not known.

Von Hafe, Barros and colleagues in order to understand the contribution of different types of adipose tissue to prostate cancer used computerized axial tomography, a technique that employs advanced x-ray technology and allows to distinguish, and individually measure, different types of adipose tissue. The team of scientists compared sixty-three prostate cancer male patients with sixty-three healthy controls from the same sex and ethnical background and with similar age, height and weight. Very interestingly, it was found that higher quantities of visceral fat, but not of subcutaneous fat, were associated with prostate cancer. This result corroborates the researchers ’ hypothesis that different fat have different effects in prostate cancer incidence. The quantity of visceral fat, however, did not correlate with the disease stage, indicating that once established, other factors contribute to the evolution of disease.

The different results found between visceral and subcutaneous fat, probably result from different biochemical substances produced by each of the adipose tissue, which will affect the body in different ways. Furthermore, contributing for the harmful effect of visceral fat is the fact that this type of adiposity tends to be metabolised by the liver into fatty acids and released into the blood what will ultimately lead to an increase of insulin in the blood. And insulin is known to be capable of induce the growth of cancerigenous cells, including cells from prostate tumours.

Von Hafe, Barros and colleagues’ work is important because it alerts to the importance of distinguish between different types of fat when calculating individual obesity levels and their potential risk to health. Furthermore, comprehension of the mechanisms leading to prostate cancer is the first step for disease prevention.

Piece researched and written by: Catarina Amorim (catarina.amorim@linacre.ox.ac.uk)

Catarina Amorim | alfa
Further information:
http://www.obesityresearch.org/cgi/content/abstract/12/12/1930

More articles from Health and Medicine:

nachricht Satellites, airport visibility readings shed light on troops' exposure to air pollution
09.12.2016 | Veterans Affairs Research Communications

nachricht Oxygen can wake up dormant bacteria for antibiotic attacks
08.12.2016 | Penn State

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>