From the February 2005 Journal of Allergy & Clinical Immunology
Researchers have identified specific asthma characteristics in children that could help determine the type of asthma treatment they will best respond to. These findings were published in the February 2005 Journal of Allergy & Clinical Immunology (JACI). The JACI is the peer-reviewed, scientific journal of the American Academy of Allergy, Asthma and Immunology (AAAAI). "Parents of children with asthma often ask: Is there a good way to determine what medication will work best in my child?" said Stanley J. Szefler, MD, FAAAAI. "These findings begin to address this question by taking a step toward enabling clinicians to better individualize asthma therapy."
Dr. Szefler and colleagues from the National Heart, Lung, and Blood Institutes (NHLBIs) Childhood Asthma Research and Education (CARE) Network found specific differences in responses to the inhaled corticosteroid, fluticasone, and the leukotriene receptor antagonist, montelukast, in children with mild-to-moderate persistentasthma.
Researchers noted that children whose asthma improved with inhaled corticosteroids had low pulmonary function and elevated markers of allergic inflammation at baseline. On the other hand, the children whose asthma was improved only by the leukotriene receptor antagonist were younger in age and had a shorter duration of the disease.
Based on these findings, researchers recommend that children with mild-to-moderate persistent asthma who have low lung function and/or elevated signs of allergic inflammation be treated daily with inhaled corticosteroids. Their findings also suggest that, in those children who have no elevated signs of allergic inflammation, a therapeutic trial of either medication can be conducted to determine which works best.
John Gardner | EurekAlert!
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