Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New nicotine-like imaging agent holds promise in PET studies, may help diagnose Alzheimer’s disease

01.02.2005


The chemical nicotine--a main ingredient in tobacco--may hold promise in the early diagnosis of Alzheimer’s disease, give insight into therapeutic interventions for nicotine addiction and possibly complement the diagnosis of certain forms of lung cancer, according to a study in the January issue of the Society of Nuclear Medicine’s Journal of Nuclear Medicine.



Researchers are examining nicotine’s cognitive, behavioral and addictive actions, and, by looking at targets in the brain where nicotine acts, researchers hope to address several major health problems, said SNM member Jogeshwar Mukherjee, Ph.D., associate professor in residence at the department of psychiatry and human behavior, Brain Imaging Center, at the University of California at Irvine (UCI). A team of researchers from UCI and the Kettering Medical Center in Dayton, Ohio, found that imaging studies with a new fluorine-18 labeled imaging agent, nifrolidine, complement other ongoing positron emission tomography (PET) studies currently underway with nicotine-like PET imaging agents.

Nifrolidine was developed to specifically bind to a receptor (protein) that is present in the human and nonhuman brain; this receptor is involved in several brain functions, particularly cognition and certain aspects of learning and memory, according to Mukherjee. By binding at the same place as nicotine, nifrolidine helps to measure how and where nicotine acts. PET studies can be performed with nifrolidine to provide information on the receptor present in various regions of the brain. "Research has shown that with Alzheimer’s disease there is a gradual loss of these receptors; therefore, there is a potential of early diagnostic value in nifrolidine-PET imaging," he said.


In addition, nicotine addiction and lung cancer may be linked to this receptor. The availability of a good PET imaging agent for this receptor will allow preclinical and clinical studies, leading to better understanding of different medical conditions and eventually helping in their diagnosis and treatment, said Mukherjee.

Additional research and work with animal subjects must be completed before this tracer can be used to demonstrate applications in human studies, said the co-author of "Synthesis and Evaluation of Nicotine á4â2 Receptor Radioligand, 5-(3’-18F-Fluoropropyl)-3-(2-(S)- Pyrrolidinylmethoxy) Pyridine, in Rodents and PET in Nonhuman Primate." The team plans to obtain complete toxicity and dosimetry data in order to obtain approval for conducting human studies.

"Synthesis and Evaluation of Nicotine á4â2 Receptor Radioligand, 5-(3’-18F-Fluoropropyl)-3-(2-(S)- Pyrrolidinylmethoxy) Pyridine, in Rodents and PET in Nonhuman Primate" was written by Sankha Chattopadhyay, Ph.D., Baogang Xue, M.D., Daphne Collins, B.E., and Rama Pichika, Ph.D., all at the department of psychiatry and human behavior, Brain Imaging Center, University of California, Irvine, Calif.; Rudy Bagnera, B.S., and Frances M. Leslie, Ph.D., both at the department of pharmacology, University of California, Irvine, Calif.; Bradley T. Christian, Ph.D., Bingzhi Shi, Ph.D., and Tanjore K. Narayanan, Ph.D., all at the department of PET/nuclear medicine, Kettering Medical Center, Dayton, Ohio; and Steven G. Potkin, M.D., and Jogeshwar Mukherjee, Ph.D., both at the department of psychiatry and human behavior, Brain Imaging Center, University of California, Irvine, Calif.

Maryann Verrillo | EurekAlert!
Further information:
http://www.snm.org

More articles from Health and Medicine:

nachricht Satellites, airport visibility readings shed light on troops' exposure to air pollution
09.12.2016 | Veterans Affairs Research Communications

nachricht Oxygen can wake up dormant bacteria for antibiotic attacks
08.12.2016 | Penn State

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Electron highway inside crystal

Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.

Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers identify potentially druggable mutant p53 proteins that promote cancer growth

09.12.2016 | Life Sciences

Scientists produce a new roadmap for guiding development & conservation in the Amazon

09.12.2016 | Ecology, The Environment and Conservation

Satellites, airport visibility readings shed light on troops' exposure to air pollution

09.12.2016 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>