Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Progesterone therapy could prevent thousands of preterm births

01.02.2005


Nearly 10,000 preterm births could have been prevented in 2002 if all pregnant women at high risk for a premature baby and eligible for weekly injections of a derivative of the hormone progesterone had received them, according to a new study published in the February issue of Obstetrics & Gynecology.



The result would have been a reduction in the overall rate of preterm birth (before 37 completed weeks gestation) in the United States of about 2 percent -- from the 2002 rate of 12.1 percent to 11.8 percent -- say Joann R. Petrini, Ph.D., M.P.H., and colleagues from the March of Dimes, the Centers for Disease Control and Prevention, the National Institute of Child Health and Human Development (NICHD), Albert Einstein College of Medicine, Maimonides Medical Center in New York, and the New Jersey and Missouri State Departments of Health who participated in the analyses.

The hormone derivative is known as 17P, short for 17 alpha-hydroxyprogesterone caproate.


"Two percent would be a modest reduction in the preterm birth rate, but preventing 10,000 premature births would be very significant," said Dr. Petrini. "Prematurity is a serious problem that affects 1 in 8 babies in the U.S., and 17P offers promise in an area where there have been few successes. In addition, we need more research into the underlying causes of prematurity to help women with other risk factors."

Assumptions used to estimate the impact of 17P on recurrent preterm birth were based on criteria from the promising findings of the clinical trial reported by Paul J. Meis, M.D., et al. for the NICHD Maternal-Fetal Medicine Units (MFMU) Network in The New England Journal of Medicine on June 12, 2003. These study results led to the 2003 Committee Opinion issued by the American College of Obstetrician’s and Gynecologists, published in the October 2003 issue of Obstetrics & Gynecology.

In the NICHD MFMU study, the use of 17P was restricted to women with singleton pregnancies and a documented history of a previous spontaneous preterm birth, who initiated prenatal care between 16 and 20 weeks gestation. When this protocol was followed, the risk of preterm birth to these eligible women was reduced by about one-third.

The authors of today’s paper estimated that in 2002, about 30,000 recurrent preterm births occurred to women who were eligible for 17P, based on a spontaneous preterm birth recurrence rate of about 22 percent.

The ACOG Committee Opinion urges more research on the role of preventing preterm birth and reminds physicians that, until new results are available, to restrict the use of 17P to pregnant women with a history of spontaneous preterm birth, singleton gestation, who start prenatal care between 16-20 weeks of pregnancy.

Premature birth is a common, serious, and growing problem in the United States, the March of Dimes says. The rate of premature birth in the United States has risen 29 percent since 1981, with more than 470,000 babies born prematurely each year.

Michele Kling | EurekAlert!
Further information:
http://www.marchofdimes.com

More articles from Health and Medicine:

nachricht New malaria analysis method reveals disease severity in minutes
14.08.2017 | University of British Columbia

nachricht New type of blood cells work as indicators of autoimmunity
14.08.2017 | Instituto de Medicina Molecular

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

Climate change: In their old age, trees still accumulate large quantities of carbon

17.08.2017 | Earth Sciences

Modern genetic sequencing tools give clearer picture of how corals are related

17.08.2017 | Life Sciences

Superconductivity research reveals potential new state of matter

17.08.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>