Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Obesity may affect accuracy of prostate screening

24.01.2005


Researchers say obesity is associated with lower prostate specific antigen (PSA) levels in men, making the screening test likely to produce unreliable results in this population. The full study is published in the March 1, 2005 issue of CANCER (http://www.interscience.wiley.com/cancer-newsroom), a peer-reviewed journal of the American Cancer Society.



Since the use of early detection tests for prostate cancer became relatively common (about 1990), the prostate cancer death rate has dropped. But it is still unclear whether the drop is a direct result of screening. Studies are underway to try to determine if early detection tests for prostate cancer in large groups of men will lower the prostate cancer death rate.

Obesity, defined as a body mass index (BMI) over 30, is a growing public health issue in the U.S., and is associated with chronic diseases such as diabetes. A landmark American Cancer Society study in April 2003 added prostate cancer to the list of cancers linked to an unhealthy body weight, with men at the highest BMI at 34 percent higher risk. Studies also show obesity is associated with poor prognostic association as well. Obese men with prostate cancer are diagnosed at more advanced stages and have higher mortality rates. Hypotheses include tumorigenic links to elevated hormones, such as estrogen and insulin-like growth factor.


Another hypothesis states that obesity may actually make available screening tests insensitive. In order to test this hypothesis, Jacques Baillargeon, Ph.D. of the University of Texas Health Science Center in San Antonio and colleagues investigated the association between BMI and PSA levels in 2779 men without prostate cancer in a study sponsored by the Early Detection Research Network of the National Cancer Institute.

The researchers found that as BMI increased, PSA linearly decreased. This finding was consistent regardless of age and race.

These findings, the authors conclude, may explain "the recent reports of inferior outcomes of prostate cancer treatment in obese men" in that they "may be caused by delayed detection" rather than biological differences in the tumor. The study implies that physicians may consider adjusting PSA values when screening for prostate cancer if men are overweight or obese.

David Greenberg | EurekAlert!
Further information:
http://www.interscience.wiley.com/cancer-newsroom
http://www.wiley.com

More articles from Health and Medicine:

nachricht A promising target for kidney fibrosis
21.04.2017 | Brigham and Women's Hospital

nachricht Stem cell transplants: activating signal paths may protect from graft-versus-host disease
20.04.2017 | Technische Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

DGIST develops 20 times faster biosensor

24.04.2017 | Physics and Astronomy

Nanoimprinted hyperlens array: Paving the way for practical super-resolution imaging

24.04.2017 | Materials Sciences

Atomic-level motion may drive bacteria's ability to evade immune system defenses

24.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>