Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Obesity may affect accuracy of prostate screening

24.01.2005


Researchers say obesity is associated with lower prostate specific antigen (PSA) levels in men, making the screening test likely to produce unreliable results in this population. The full study is published in the March 1, 2005 issue of CANCER (http://www.interscience.wiley.com/cancer-newsroom), a peer-reviewed journal of the American Cancer Society.



Since the use of early detection tests for prostate cancer became relatively common (about 1990), the prostate cancer death rate has dropped. But it is still unclear whether the drop is a direct result of screening. Studies are underway to try to determine if early detection tests for prostate cancer in large groups of men will lower the prostate cancer death rate.

Obesity, defined as a body mass index (BMI) over 30, is a growing public health issue in the U.S., and is associated with chronic diseases such as diabetes. A landmark American Cancer Society study in April 2003 added prostate cancer to the list of cancers linked to an unhealthy body weight, with men at the highest BMI at 34 percent higher risk. Studies also show obesity is associated with poor prognostic association as well. Obese men with prostate cancer are diagnosed at more advanced stages and have higher mortality rates. Hypotheses include tumorigenic links to elevated hormones, such as estrogen and insulin-like growth factor.


Another hypothesis states that obesity may actually make available screening tests insensitive. In order to test this hypothesis, Jacques Baillargeon, Ph.D. of the University of Texas Health Science Center in San Antonio and colleagues investigated the association between BMI and PSA levels in 2779 men without prostate cancer in a study sponsored by the Early Detection Research Network of the National Cancer Institute.

The researchers found that as BMI increased, PSA linearly decreased. This finding was consistent regardless of age and race.

These findings, the authors conclude, may explain "the recent reports of inferior outcomes of prostate cancer treatment in obese men" in that they "may be caused by delayed detection" rather than biological differences in the tumor. The study implies that physicians may consider adjusting PSA values when screening for prostate cancer if men are overweight or obese.

David Greenberg | EurekAlert!
Further information:
http://www.interscience.wiley.com/cancer-newsroom
http://www.wiley.com

More articles from Health and Medicine:

nachricht Researchers identify new way to unmask melanoma cells to the immune system
17.01.2018 | Duke University Medical Center

nachricht Study advances gene therapy for glaucoma
17.01.2018 | University of Wisconsin-Madison

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

Im Focus: A thermometer for the oceans

Measurement of noble gases in Antarctic ice cores

The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Polymers Based on Boron?

18.01.2018 | Life Sciences

Bioengineered soft microfibers improve T-cell production

18.01.2018 | Life Sciences

World’s oldest known oxygen oasis discovered

18.01.2018 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>