Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Obesity may affect accuracy of prostate screening

24.01.2005


Researchers say obesity is associated with lower prostate specific antigen (PSA) levels in men, making the screening test likely to produce unreliable results in this population. The full study is published in the March 1, 2005 issue of CANCER (http://www.interscience.wiley.com/cancer-newsroom), a peer-reviewed journal of the American Cancer Society.



Since the use of early detection tests for prostate cancer became relatively common (about 1990), the prostate cancer death rate has dropped. But it is still unclear whether the drop is a direct result of screening. Studies are underway to try to determine if early detection tests for prostate cancer in large groups of men will lower the prostate cancer death rate.

Obesity, defined as a body mass index (BMI) over 30, is a growing public health issue in the U.S., and is associated with chronic diseases such as diabetes. A landmark American Cancer Society study in April 2003 added prostate cancer to the list of cancers linked to an unhealthy body weight, with men at the highest BMI at 34 percent higher risk. Studies also show obesity is associated with poor prognostic association as well. Obese men with prostate cancer are diagnosed at more advanced stages and have higher mortality rates. Hypotheses include tumorigenic links to elevated hormones, such as estrogen and insulin-like growth factor.


Another hypothesis states that obesity may actually make available screening tests insensitive. In order to test this hypothesis, Jacques Baillargeon, Ph.D. of the University of Texas Health Science Center in San Antonio and colleagues investigated the association between BMI and PSA levels in 2779 men without prostate cancer in a study sponsored by the Early Detection Research Network of the National Cancer Institute.

The researchers found that as BMI increased, PSA linearly decreased. This finding was consistent regardless of age and race.

These findings, the authors conclude, may explain "the recent reports of inferior outcomes of prostate cancer treatment in obese men" in that they "may be caused by delayed detection" rather than biological differences in the tumor. The study implies that physicians may consider adjusting PSA values when screening for prostate cancer if men are overweight or obese.

David Greenberg | EurekAlert!
Further information:
http://www.interscience.wiley.com/cancer-newsroom
http://www.wiley.com

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

Physicists discover mechanism behind granular capillary effect

24.05.2017 | Physics and Astronomy

Measured for the first time: Direction of light waves changed by quantum effect

24.05.2017 | Physics and Astronomy

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>