University of Pittsburgh findings published in leading European journal
Reduced blood concentrations of a protein called adiponectin appear to indicate a significant risk of cardiovascular disease in one of the first studies to focus on risk of the disorder among patients with diabetes mellitus type 1, previously known as juvenile diabetes. Recent studies suggest that adiponectin, a protein specific to fat tissue, is involved in obesity, diabetes and heart disease. Results of the study are published in the January issue of Diabetologia, a leading journal affiliated with the European Association for the Study of Diabetes.
"Most studies looking at adiponectin concentrations have been in the non-diabetic population or in people with type 2 diabetes," said Trevor Orchard, M.D., professor of epidemiology, medicine and pediatrics at the University of Pittsburgh Graduate School of Public Health (GSPH) and senior author of the study. "Given our previous work linking insulin resistance to heart disease in type 1 diabetes, we wanted to evaluate whether adiponectin levels in these individuals might be predictive of future cardiac events." Adiponectin has been closely linked with insulin resistance, a known risk factor for heart disease.
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