New research published in the premier issue of Cell Metabolism finds that a single brain region is sufficient for normal control of blood sugar and activity level by the fat hormone leptin. The same region also exerts significant, though more modest, control over leptin’s effects on body weight. The findings in mice provide insight into potential mechanisms underlying type II diabetes and suggest new avenues for treatment, according to the researchers.
Secreted by fat cells, leptin signals the status of the body’s energy content to the brain and is required for normal body weight and glucose balance. Mice lacking leptin develop obesity, diabetes, and inactivity, among other symptoms.
The new results suggest that leptin signaling acts directly on the brain region known as the hypothalamic arcuate nucleus (ARH) to control insulin and glucose levels in the bloodstream, report Joel Elmquist and Bradford Lowell, both of Beth Israel Deaconess Medical Center and Harvard Medical School, and their colleagues. ARH neurons also mediate the majority, if not all, of the hormone’s action on locomotor activity, they found.
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