Mayo Clinic recommends broadening treatment to battle recurrence of endometrial cancer
Mayo Clinic researchers studying endometrial cancer have found that patients at risk for relapse based on identified risk factors had a 46 percent probability of experiencing recurrence within five years despite treatment with state-of-the-art therapy.
The studys findings are important for women deemed at risk because they might need additional treatment, which physicians should consider in their treatment plans for their patients, says Karl Podratz, M.D., Ph.D., the studys lead researcher.
The risk factors the researchers identified were specific characteristics of tissues that had been removed during surgery and were analyzed by microscope. Researchers also said risk factors included whether the tumors were confined to the uterus or if the disease had spread outside the uterus.
In the United States, endometrial cancer is the most common malignancy of the female reproductive tract. Only breast, colon and lung cancers are more prevalent in women. During 2004, it was estimated 40,320 new cases of endometrial cancer would be diagnosed in the United States and 7,090 women would die from the disease.
The study looked at 1,109 patients with endometrial cancer who had surgical treatment at Mayo Clinic in Rochester from 1984 to 1996. Based on data from their medical records, 915 patients with endometrial cancer met the following criteria to be included in the study: treatment included hysterectomy, and no other malignancy was diagnosed within five years before or after the diagnosis of endometrial cancer.
"The 46 percent recurrence rate for the at-risk patients among the expected cases of newly diagnosed endometrial cancer in 2004 is close to the number of deaths the disease is expected to cause in that period," says Dr. Podratz. "We feel that to maximize outcomes, approximately one-third of the patients with endometrial cancer in the United States, or about 14,000 women, would potentially benefit from enrollment in clinical trials addressing the new target-based therapeutic approach."
The new approach for treatment would be based on the inclusion of risk factors identified in previous studies and categorization of patients according to their risks for different patterns of recurrence, such as in the lungs, abdomen or lymph nodes. In doing this, physicians would be able to better predict and focus treatments on anticipated routes of the disease and its relapse.
Lisa Lucier | EurekAlert!
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
Researchers from the University of Miami (UM) Rosenstiel School of Marine and Atmospheric Science, the Italian Space Agency (ASI), and the Instituto Geofisico--Escuela Politecnica Nacional (IGEPN) of Ecuador, showed an increasing volcanic danger on Cotopaxi in Ecuador using a powerful technique known as Interferometric Synthetic Aperture Radar (InSAR).
The Andes region in which Cotopaxi volcano is located is known to contain some of the world's most serious volcanic hazard. A mid- to large-size eruption has...