Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Reduced calorie and carbohydrate diet slows progression of Alzheimer’s disease in mouse model

13.01.2005


A Mount Sinai School of Medicine led study is the first to suggest that Alzheimer’s disease may be slowed and possibly prevented through dietary changes



Researchers found that a low carbohydrate diet that reduced total caloric intake by 30% prevented the development of a fundamental feature of Alzheimer’s disease (AD) in mice genetically engineered to develop the disease. The diet eliminated amyloid plaque development, which is the underlying pathology in AD. The study, published in the February issue of The FASEB Journal Express, is the first to demonstrate that a change in diet can slow and possibly prevent Alzheimer’s diseases.

"While it is far too early for us to make specific recommendations for human diets," said Giulio Maria Pasinetti, MD, PhD, Professor of Psychiatry, Neurosciences and Geriatrics and Adult Development at Mount Sinai School of Medicine and primary investigator on the study, "these findings provide the first solid evidence that dietary changes may provide a new approach to treatment and prevention of this devastating disease."


Dr. Pasinetti and his colleagues found that mice did not develop the physiological markers of the disease when they were fed a reduced carbohydrate diet that provided 70% of the calories eaten by similar mice who were allowed to eat ad-libitum. The strain of mice used in the study was genetically engineered to produce what are known as amyloidogenic â-amyloid peptides in the brain, resulting in formation of amyloid plaques which are known to be the fundamental problem in Alzheimer’ disease. Of the mice fed ad-libitum, 100% developed these plaques. No plaque development was detected in the mice fed a carbohydrate and calorie restricted diet.

The diet regimen was begun when the mice were 3-months old, which is considered young adult and is prior to the age at when this Alzheimer’s disease mouse model begins to develop plaques in the brain. The presence of plaques was evaluated at 12 months of age, which is an age at which plaques are known to be well developed in this strain.

The investigators found that anti-amyloidogenic activities were increased in mice fed the restricted diet. In other words, the calorie restricted diet activated pathways that break down amyloidogenic â-amyloid peptides in the brain before they form the plaques characteristic of AD.

"Since the diet only reduced calories by 30%, (based on carbohydrate) the mice developed normally," said Dr. Pasinetti. "While they did not gain weight like the mice in the control group, they did not loose weight either and remained within the boundaries considered a healthy weight. Nonetheless, this rather mild change in diet resulted in a remarkable measure of disease prevention. There is epidemiological evidence that humans who consume reduced calorie diets have a lower incidence of AD. Our investigation provides a possible rational for this observation and possible mechanisms through which caloric reduction may provide protection in Alzheimer’s disease."

Ongoing studies are investigating whether or not the prevention of plaque development in these mice also prevents behavioral decline and clinical studies are currently being designed at Mount Sinai School of Medicine to explore the applicability of this experimental evidence in Alzheimer’s disease cases.

Mount Sinai Press Office | EurekAlert!
Further information:
http://www.mssm.edu

More articles from Health and Medicine:

nachricht Study suggests possible new target for treating and preventing Alzheimer's
02.12.2016 | Oregon Health & Science University

nachricht The first analysis of Ewing's sarcoma methyloma opens doors to new treatments
01.12.2016 | IDIBELL-Bellvitge Biomedical Research Institute

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>