Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Reduced calorie and carbohydrate diet slows progression of Alzheimer’s disease in mouse model

13.01.2005


A Mount Sinai School of Medicine led study is the first to suggest that Alzheimer’s disease may be slowed and possibly prevented through dietary changes



Researchers found that a low carbohydrate diet that reduced total caloric intake by 30% prevented the development of a fundamental feature of Alzheimer’s disease (AD) in mice genetically engineered to develop the disease. The diet eliminated amyloid plaque development, which is the underlying pathology in AD. The study, published in the February issue of The FASEB Journal Express, is the first to demonstrate that a change in diet can slow and possibly prevent Alzheimer’s diseases.

"While it is far too early for us to make specific recommendations for human diets," said Giulio Maria Pasinetti, MD, PhD, Professor of Psychiatry, Neurosciences and Geriatrics and Adult Development at Mount Sinai School of Medicine and primary investigator on the study, "these findings provide the first solid evidence that dietary changes may provide a new approach to treatment and prevention of this devastating disease."


Dr. Pasinetti and his colleagues found that mice did not develop the physiological markers of the disease when they were fed a reduced carbohydrate diet that provided 70% of the calories eaten by similar mice who were allowed to eat ad-libitum. The strain of mice used in the study was genetically engineered to produce what are known as amyloidogenic â-amyloid peptides in the brain, resulting in formation of amyloid plaques which are known to be the fundamental problem in Alzheimer’ disease. Of the mice fed ad-libitum, 100% developed these plaques. No plaque development was detected in the mice fed a carbohydrate and calorie restricted diet.

The diet regimen was begun when the mice were 3-months old, which is considered young adult and is prior to the age at when this Alzheimer’s disease mouse model begins to develop plaques in the brain. The presence of plaques was evaluated at 12 months of age, which is an age at which plaques are known to be well developed in this strain.

The investigators found that anti-amyloidogenic activities were increased in mice fed the restricted diet. In other words, the calorie restricted diet activated pathways that break down amyloidogenic â-amyloid peptides in the brain before they form the plaques characteristic of AD.

"Since the diet only reduced calories by 30%, (based on carbohydrate) the mice developed normally," said Dr. Pasinetti. "While they did not gain weight like the mice in the control group, they did not loose weight either and remained within the boundaries considered a healthy weight. Nonetheless, this rather mild change in diet resulted in a remarkable measure of disease prevention. There is epidemiological evidence that humans who consume reduced calorie diets have a lower incidence of AD. Our investigation provides a possible rational for this observation and possible mechanisms through which caloric reduction may provide protection in Alzheimer’s disease."

Ongoing studies are investigating whether or not the prevention of plaque development in these mice also prevents behavioral decline and clinical studies are currently being designed at Mount Sinai School of Medicine to explore the applicability of this experimental evidence in Alzheimer’s disease cases.

Mount Sinai Press Office | EurekAlert!
Further information:
http://www.mssm.edu

More articles from Health and Medicine:

nachricht Penn studies find promise for innovations in liquid biopsies
30.03.2017 | University of Pennsylvania School of Medicine

nachricht 'On-off switch' brings researchers a step closer to potential HIV vaccine
30.03.2017 | University of Nebraska-Lincoln

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

'On-off switch' brings researchers a step closer to potential HIV vaccine

30.03.2017 | Health and Medicine

Penn studies find promise for innovations in liquid biopsies

30.03.2017 | Health and Medicine

An LED-based device for imaging radiation induced skin damage

30.03.2017 | Medical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>