Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Melanoma treatment lesson

05.01.2005


For some years ago now biochemotherapy has replaced chemotherapy for the treatment of melanomas. In biochemotherapy, together with chemotherapuetic agents, substances that activate the patient’s immune system are used with the objective of obtaining a reinforced immune system in order to help the patient overcome the illness.



Now, however, the activity of a number of these activating substances has been questioned, given that they have not been found to extend the life of the patient compared to that undergoing the habitual chemotherapy treatment. This is why these activating substances and biochemotherapy treatment itself are being questioned and a number of studies suggest the removal of such substances from medication.

Beneficial or prejudicial?


In the Public University of the Basque Country, in 1992, they discovered that one of these activating substances had a prejudicial effect. We are referring to interleukin-2 (IL-2). This activating substance activates the immune system, but also the proliferation of tumorous cells. Thus, metastasis extends even further and the patient does not benefit at all.

Though armed with this fact, the researchers at the Basque University did not discard the possibility that this substance, if used appropriately, could turn out to be beneficial, i.e. its activity had to be better modulated.

The research began with the aim of discovering the processes that activate IL-2 within the cells. Concretely, IL-2 augments the level of glutathionation (GSH) within the cells, glutathione, in turn, being an element that accelerates cellular proliferation. But this GSH compound is found in all cells and, therefore, in cancerous cells. And this is why the metastasis regenerates.

Thus, in order to obtain beneficial effects using IL-2, the glutation in tumorous cells would have to be reduced in an alternative manner, and this was achieved by means of oxothiazolidine-carboxilate (OTZ).

Finding the appropriate patern of dosage

The OTZ compound had an important function; it had to reduce the glutation level in tumorous cells while leaving the healthy cells alone. In order to achieve this target it was essential to find the most suitable dosage for the administering of all the components, given that the obtained effect greatly depended on the order in which each of the substances was administered.

After a number of years of investigation, researchers have discovered this pattern. Firstly, the OTZ has to be given, then the chemotherapeutic agent and, finally, the IL-2 is administered. They are not single doses and the treatment is much more complex, but the order has to be this one.

Following this dosage pattern, researchers managed to reduce one of the most serious problems in chemotherapy - toxicity. This meant that the chemotherapy dosage could be increased and, if the investigation turned out to be successful, that the life of the patient would be extended. The quality of life would also be enhanced with this new treatment.

This has been demonstrated through trials over many years, starting with mice and, currently, in vitro trials are being undertaken with human cells. Positive results have been achieved in all these trials, the conclusion being that a substance should not be rejected out of hand as it may well be usage of the substance and not the substance itself which is not suitable.

Garazi Andonegi | alfa
Further information:
http://www.basqueresearch.com
http://www.elhuyar.com

More articles from Health and Medicine:

nachricht Antibiotic effective against drug-resistant bacteria in pediatric skin infections
17.02.2017 | University of California - San Diego

nachricht Tiny magnetic implant offers new drug delivery method
14.02.2017 | University of British Columbia

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Biocompatible 3-D tracking system has potential to improve robot-assisted surgery

17.02.2017 | Medical Engineering

Real-time MRI analysis powered by supercomputers

17.02.2017 | Medical Engineering

Antibiotic effective against drug-resistant bacteria in pediatric skin infections

17.02.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>