Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Melanoma treatment lesson

05.01.2005


For some years ago now biochemotherapy has replaced chemotherapy for the treatment of melanomas. In biochemotherapy, together with chemotherapuetic agents, substances that activate the patient’s immune system are used with the objective of obtaining a reinforced immune system in order to help the patient overcome the illness.



Now, however, the activity of a number of these activating substances has been questioned, given that they have not been found to extend the life of the patient compared to that undergoing the habitual chemotherapy treatment. This is why these activating substances and biochemotherapy treatment itself are being questioned and a number of studies suggest the removal of such substances from medication.

Beneficial or prejudicial?


In the Public University of the Basque Country, in 1992, they discovered that one of these activating substances had a prejudicial effect. We are referring to interleukin-2 (IL-2). This activating substance activates the immune system, but also the proliferation of tumorous cells. Thus, metastasis extends even further and the patient does not benefit at all.

Though armed with this fact, the researchers at the Basque University did not discard the possibility that this substance, if used appropriately, could turn out to be beneficial, i.e. its activity had to be better modulated.

The research began with the aim of discovering the processes that activate IL-2 within the cells. Concretely, IL-2 augments the level of glutathionation (GSH) within the cells, glutathione, in turn, being an element that accelerates cellular proliferation. But this GSH compound is found in all cells and, therefore, in cancerous cells. And this is why the metastasis regenerates.

Thus, in order to obtain beneficial effects using IL-2, the glutation in tumorous cells would have to be reduced in an alternative manner, and this was achieved by means of oxothiazolidine-carboxilate (OTZ).

Finding the appropriate patern of dosage

The OTZ compound had an important function; it had to reduce the glutation level in tumorous cells while leaving the healthy cells alone. In order to achieve this target it was essential to find the most suitable dosage for the administering of all the components, given that the obtained effect greatly depended on the order in which each of the substances was administered.

After a number of years of investigation, researchers have discovered this pattern. Firstly, the OTZ has to be given, then the chemotherapeutic agent and, finally, the IL-2 is administered. They are not single doses and the treatment is much more complex, but the order has to be this one.

Following this dosage pattern, researchers managed to reduce one of the most serious problems in chemotherapy - toxicity. This meant that the chemotherapy dosage could be increased and, if the investigation turned out to be successful, that the life of the patient would be extended. The quality of life would also be enhanced with this new treatment.

This has been demonstrated through trials over many years, starting with mice and, currently, in vitro trials are being undertaken with human cells. Positive results have been achieved in all these trials, the conclusion being that a substance should not be rejected out of hand as it may well be usage of the substance and not the substance itself which is not suitable.

Garazi Andonegi | alfa
Further information:
http://www.basqueresearch.com
http://www.elhuyar.com

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>