Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Arsenic ingestion from well water associated with increased risk of lung cancer

22.12.2004


Residents of Taiwan who consumed drinking water with high levels of arsenic have a higher risk of lung cancer, with cigarette smokers from this group having an even greater risk, according to a study in the December 22/29 issue of JAMA.



Arsenic is a naturally occurring element in soil, and can contaminate drinking water, according to background information in the article. Residents of the southwestern and northeastern coasts of Taiwan had been drinking well water contaminated with a high concentration of arsenic before the establishment of the public tap water system.

Chi-Ling Chen, Ph.D., of the College of Public Health, National Taiwan University, Taipei, Taiwan, and colleagues conducted a study to determine the dose-response relationship between ingested arsenic and lung cancer risk and the added effect of cigarette smoking on this risk.


The study included 2,503 residents in southwestern and 8,088 in northeastern arsenic-endemic areas in Taiwan, who were followed up for an average period of 8 years. Information on arsenic exposure, cigarette smoking, and other risk factors was collected at enrollment through standardized questionnaire interview.

During the study followup period, there were 139 newly diagnosed cases of lung cancer. Residents with the highest level of arsenic exposure had a 3.29 times increased risk for lung cancer, after adjusting for various factors including age, sex, and cigarette smoking status at recruitment. Among nonsmokers, those who were exposed to the highest arsenic level had about twice the risk for lung cancer when compared with those with the lowest level of exposure. Among participants with the lowest arsenic level, those who had the highest cumulative cigarette smoking exposure had a 4-fold risk of lung cancer compared with nonsmokers. When compared with nonsmokers with the lowest levels of arsenic exposure, those who consumed well water with the highest arsenic levels and smoked for more than 25 pack-years had a more than 11-fold risk of lung cancer.

"Approximately 32 percent to 55 percent of lung cancer cases were estimated to be attributable to the combined effect of cigarette smoking and ingested arsenic, depending on the levels of both exposures," the authors write. "The synergy indices ranged from 1.62 to 2.52, indicating a synergistic effect of ingested arsenic and cigarette smoking on lung cancer."

"The reductions in cigarette smoking would likely reduce the lung cancer risk accompanied by exposure to arsenic, and similarly, reductions in arsenic exposure would reduce the lung cancer risk among cigarette smokers. Appropriate public health interventions, such as cigarette smoking cessation programs and reduction in arsenic concentration of drinking water, are warranted. Furthermore, it is essential to take cigarette smoking into consideration in the risk assessment and the determination of the maximal contamination level of arsenic in drinking water," the authors conclude.

Chien-Jen Chen, Sc.D. | EurekAlert!
Further information:
http://www.jama.com

More articles from Health and Medicine:

nachricht How cancer metastasis happens: Researchers reveal a key mechanism
19.01.2018 | Weill Cornell Medicine

nachricht Researchers identify new way to unmask melanoma cells to the immune system
17.01.2018 | Duke University Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Let the good tubes roll

19.01.2018 | Materials Sciences

How cancer metastasis happens: Researchers reveal a key mechanism

19.01.2018 | Health and Medicine

Meteoritic stardust unlocks timing of supernova dust formation

19.01.2018 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>