Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Arsenic ingestion from well water associated with increased risk of lung cancer

22.12.2004


Residents of Taiwan who consumed drinking water with high levels of arsenic have a higher risk of lung cancer, with cigarette smokers from this group having an even greater risk, according to a study in the December 22/29 issue of JAMA.



Arsenic is a naturally occurring element in soil, and can contaminate drinking water, according to background information in the article. Residents of the southwestern and northeastern coasts of Taiwan had been drinking well water contaminated with a high concentration of arsenic before the establishment of the public tap water system.

Chi-Ling Chen, Ph.D., of the College of Public Health, National Taiwan University, Taipei, Taiwan, and colleagues conducted a study to determine the dose-response relationship between ingested arsenic and lung cancer risk and the added effect of cigarette smoking on this risk.


The study included 2,503 residents in southwestern and 8,088 in northeastern arsenic-endemic areas in Taiwan, who were followed up for an average period of 8 years. Information on arsenic exposure, cigarette smoking, and other risk factors was collected at enrollment through standardized questionnaire interview.

During the study followup period, there were 139 newly diagnosed cases of lung cancer. Residents with the highest level of arsenic exposure had a 3.29 times increased risk for lung cancer, after adjusting for various factors including age, sex, and cigarette smoking status at recruitment. Among nonsmokers, those who were exposed to the highest arsenic level had about twice the risk for lung cancer when compared with those with the lowest level of exposure. Among participants with the lowest arsenic level, those who had the highest cumulative cigarette smoking exposure had a 4-fold risk of lung cancer compared with nonsmokers. When compared with nonsmokers with the lowest levels of arsenic exposure, those who consumed well water with the highest arsenic levels and smoked for more than 25 pack-years had a more than 11-fold risk of lung cancer.

"Approximately 32 percent to 55 percent of lung cancer cases were estimated to be attributable to the combined effect of cigarette smoking and ingested arsenic, depending on the levels of both exposures," the authors write. "The synergy indices ranged from 1.62 to 2.52, indicating a synergistic effect of ingested arsenic and cigarette smoking on lung cancer."

"The reductions in cigarette smoking would likely reduce the lung cancer risk accompanied by exposure to arsenic, and similarly, reductions in arsenic exposure would reduce the lung cancer risk among cigarette smokers. Appropriate public health interventions, such as cigarette smoking cessation programs and reduction in arsenic concentration of drinking water, are warranted. Furthermore, it is essential to take cigarette smoking into consideration in the risk assessment and the determination of the maximal contamination level of arsenic in drinking water," the authors conclude.

Chien-Jen Chen, Sc.D. | EurekAlert!
Further information:
http://www.jama.com

More articles from Health and Medicine:

nachricht Researchers release the brakes on the immune system
18.10.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Norovirus evades immune system by hiding out in rare gut cells
12.10.2017 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Terahertz spectroscopy goes nano

20.10.2017 | Information Technology

Strange but true: Turning a material upside down can sometimes make it softer

20.10.2017 | Materials Sciences

NRL clarifies valley polarization for electronic and optoelectronic technologies

20.10.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>