Pharmacogenomics, the study of genetic variability in the way individuals respond to medicines, has the potential to spark a major, technology-driven restructuring of the health care and pharmaceuticals industries, according to a commentary published in the current issue of Nature Medicine by faculty of the Indiana University Program in Pharmacogenomics, Ethics, and Public Policy.
Commentary co-authors Barbara Evans, Ph.D., J.D., David Flockhart, M.D., Ph.D.,and Eric Meslin, Ph.D., see pharmacogenomics, which matches drugs to an individuals specific genetic makeup, as having major implications for the way health care will be delivered and financed in the future.
Pharmacogenomics has the potential to reduce "trial and error" in health care through tests that can identify, in advance, which patients are likely to have a good response to a particular drug therapy. The goal is to target specific drugs at specific patients, using genetic information to increase treatment successes and reduce adverse reactions.
Cindy Fox Aisen | EurekAlert!
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Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
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