Could lead to novel approaches in the treatment of HIV infected individuals
CANVAC, the Canadian Network for Vaccines and Immunotherapeutics, is proud to announce the development of a new method to assess how well the thymus (an organ located at the base of the neck) works and the discovery of a functional abnormality of this organ in HIV-infected individuals.
The team of investigators led by Dr. Rafick-Pierre Sékaly, professor at Université de Montréal, scientist at the CHUM Research Centre, and Scientific Director and Program Leader of CANVAC, publishes today its discoveries in Immunity, a prestigious scientific journal. This work was performed in collaboration with investigators from the Research Institute of the McGill University Health Centre as well as from France and Israel.
Using only blood samples, these researchers first developed a method to assess how well the thymus functions. The thymus is involved in the development of T-lymphocytes, an essential component of the immune system. T-lymphocytes also happen to be HIV’s preferred targets for infection. The researchers then used this method to study blood samples from patients that had been recently infected with HIV and found that, already in the first months following the onset of infection, thymic function is decreased. Such a decrease results in a lowered T-lymphocyte production by the thymus.
These findings pave the way to the development of novel immunotherapies of HIV-infected individuals. Such immunotherapies could be also applicable to patients requiring bone marrow transplantation to cure their cancer.
MRI contrast agent locates and distinguishes aggressive from slow-growing breast cancer
25.09.2017 | Case Western Reserve University
Investigators may unlock mystery of how staph cells dodge the body's immune system
22.09.2017 | Cedars-Sinai Medical Center
Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.
A warming planet
Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.
The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...
Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.
Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...
19.09.2017 | Event News
12.09.2017 | Event News
06.09.2017 | Event News
25.09.2017 | Physics and Astronomy
25.09.2017 | Life Sciences
25.09.2017 | Physics and Astronomy