BACKGROUND: Insulin-degrading enzyme (IDE) is a protein known to play a role in eliminating amyloid peptides that cause destructive plaques and tangles in the brains of Alzheimers patients. Until now, little has been known about the cellular and molecular regulation of IDE.
FINDINGS: Using animal models and human tissue, the research team 1) identified a shortfall of IDE protein in the brains of Alzheimers disease patients; 2) found a cause-effect relationship between insulin signaling and increased production of IDE, and 3) demonstrated that a low-fat diet high in fish and soy can increase production of IDE.
IMPACT: The findings for the first time explain the association between insulin-resistant Type 2 diabetes and Alzheimers disease, and demonstrate the ability to manipulate levels of the protective IDE protein through diet.
Dan Page | EurekAlert!
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