USC study finds differences in survival according to lymphoma type in post-HAART era
When it comes to treating HIV-positive patients with blood cancers, not all lymphomas are created equal, according to hematologists from the University of Southern California. Although physicians have treated all types of lymphomas in HIV/AIDS patients with the same drug regimens, researchers from the USC/Norris Comprehensive Cancer Center and Hospital say the drugs are significantly more effective in patients with diffuse large-cell lymphoma, or DLCL, than in patients with small non-cleaved, or SNC, lymphoma. The findings, reported at the 46th Annual Meeting of the American Society of Hematology, suggest that researchers rethink the practice of using the same uniform treatment for everyone with AIDS-related lymphomas.
"Lymphoma is not one disease, but rather represents a group of over 30 different entities. Even lymphomas that were thought to be quite uniform and homogeneous are now recognized as being made up of different variations or sub-types. It will be important for scientists and physicians to recognize these various types, since optimal therapy in the future will probably differ for these sub-types of disease," says senior author Alexandra M. Levine, M.D., Distinguished Professor of Medicine, chief of hematology at the Keck School of Medicine of USC and medical director of the USC/Norris Cancer Hospital.
Sarah Huoh | EurekAlert!
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