Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Physicians may need to dig deeper when treating HIV-related lymphomas

07.12.2004


USC study finds differences in survival according to lymphoma type in post-HAART era

When it comes to treating HIV-positive patients with blood cancers, not all lymphomas are created equal, according to hematologists from the University of Southern California. Although physicians have treated all types of lymphomas in HIV/AIDS patients with the same drug regimens, researchers from the USC/Norris Comprehensive Cancer Center and Hospital say the drugs are significantly more effective in patients with diffuse large-cell lymphoma, or DLCL, than in patients with small non-cleaved, or SNC, lymphoma. The findings, reported at the 46th Annual Meeting of the American Society of Hematology, suggest that researchers rethink the practice of using the same uniform treatment for everyone with AIDS-related lymphomas.

"Lymphoma is not one disease, but rather represents a group of over 30 different entities. Even lymphomas that were thought to be quite uniform and homogeneous are now recognized as being made up of different variations or sub-types. It will be important for scientists and physicians to recognize these various types, since optimal therapy in the future will probably differ for these sub-types of disease," says senior author Alexandra M. Levine, M.D., Distinguished Professor of Medicine, chief of hematology at the Keck School of Medicine of USC and medical director of the USC/Norris Cancer Hospital.



The USC hematologists reviewed records of more than 350 patients with the AIDS-related lymphomas treated at USC/Norris between 1982 and early 2004; 135 patients had SNC and 227 patients had DLCL.

The researchers looked at cases occurring before the advent of highly active antiretroviral therapy, or HAART, in 1996, as well as after the introduction of the successful anti-HIV therapy. They saw 117 SNC cases and 143 DLCL cases before HAART, and 18 SNC and 84 DLCL cases after HAART.

Throughout the period, all lymphoma patients were treated for their cancers with one of two equivalent, common chemotherapy combinations: cyclophosphamide, vincristine, adriamycin and prednisone; or methotrexate, bleomycin, adriamycin, cyclophosphamide, vincristine and dexamethasone.

USC/Norris researchers found that before HAART, overall survival of SNC and DLCL patients was about the same-about six or seven months. But after HAART, patients with DLCL began living significantly longer. DLCL patients’ average survival time after HAART’s 1996 introduction was 38 months-more than six times as long as SNC patients’ average survival time of 5.6 months.

The researchers also found that SNC patients were more likely than DLCL patients to have secondary cancer in their bone marrow, liver and kidneys. "Prior to the availability of effective treatment against HIV, patients with AIDS-related lymphoma often died of serious infections before they could receive adequate or optimal chemotherapy; the survival of these patients was quite short, in the range of only six months," Levine says. "Importantly, effective anti-HIV treatment has now allowed these patients to receive chemotherapy, and to benefit from it.

"However, our study has shown that not all types of lymphoma are the same, and different treatments will be required to achieve optimal results in these individuals. We expect that our study will eventually serve to change the way in which patients with AIDS-related Burkitt lymphoma are treated."

Sarah Huoh | EurekAlert!
Further information:
http://www.usc.edu

More articles from Health and Medicine:

nachricht One gene closer to regenerative therapy for muscular disorders
01.06.2017 | Cincinnati Children's Hospital Medical Center

nachricht The gut microbiota plays a key role in treatment with classic diabetes medication
01.06.2017 | University of Gothenburg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

Im Focus: Optoelectronic Inline Measurement – Accurate to the Nanometer

Germany counts high-precision manufacturing processes among its advantages as a location. It’s not just the aerospace and automotive industries that require almost waste-free, high-precision manufacturing to provide an efficient way of testing the shape and orientation tolerances of products. Since current inline measurement technology not yet provides the required accuracy, the Fraunhofer Institute for Laser Technology ILT is collaborating with four renowned industry partners in the INSPIRE project to develop inline sensors with a new accuracy class. Funded by the German Federal Ministry of Education and Research (BMBF), the project is scheduled to run until the end of 2019.

New Manufacturing Technologies for New Products

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

A new technique isolates neuronal activity during memory consolidation

22.06.2017 | Life Sciences

Plant inspiration could lead to flexible electronics

22.06.2017 | Materials Sciences

A rhodium-based catalyst for making organosilicon using less precious metal

22.06.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>