Finding could dampen contagiousness of individuals most likely to spread germs when sick
Some individuals exhale many more pathogen-laden droplets than others in the course of ordinary breathing, scientists have found, but oral administration of a safe saline spray every six hours might slash exhalation of germs in this group by an average 72 percent.
The researchers, at Harvard University and biotechnology firms Pulmatrix and Inamed, report results from their clinical study of 11 healthy males this week on the web site of the Proceedings of the National Academy of Sciences. Their work may help decrease the spread of bacteria and viruses responsible for airborne infectious diseases such as influenza, tuberculosis, and SARS.
"We found a sharp demarcation between individuals who are high and low producers of bioaerosols, small droplets of fluid exhaled from the lungs that may carry airborne pathogens," says lead author David A. Edwards, Gordon McKay Professor of the Practice of Biomedical Engineering in Harvards Division of Engineering and Applied Sciences. "Roughly half our subjects exhaled tens of bioaerosol particles per liter, while the other half exhaled thousands of these particles. The number of exhaled particles varied dramatically over time and among subjects, ranging from a low of one particle per liter to a high of more than 10,000."
Steve Bradt | EurekAlert!
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Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
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Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
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