Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Anorexia and bone mass

25.11.2004


A multidisciplinary paediatrics research team has been awarded the “Amagoia” prize by the Sociedad Vasco-Navarra de Pediatría for its work, “Study of bone mass and its determinant factors in female children and adolescents affected by eating habit disorders”. The research was led by Dr. Cristina Azcona, responsible for the Paediatric Endocrinology Unit at the Department of paediatrics at the University Hospital in Navarre.



The patients affected by eating habit disorders are at greater risk from developing osteopenia and osteoporosis compared to the healthy population, mainly due to their state of malnutrition and hypogonadism. The aim of this research was to measure the bone mass in female children and adolescents with eating habit disorders by means of two techniques of measurement: bone densitometry (a technique also known as DEXA or Dual Energy X-ray Absorptiometry) and osteosonography.

The technique conventionally employed to assess bone mass is DEXA although, in recent years, the systems using ultrasounds (such as osteosonography) are being more frequently applied – especially amongst women during menopause. The use of osteosonography in child patients is not widespread as yet. Measurement systems applying this technique generally determine the bone mass in the calcaneum (the great bone of the heel) or the phalanges of the hand. This last system is the one that was used for this research.


It has the advantage of being portable, cheaper than DEXA and does not emit radiation, and so was thought particularly suitable for measuring bone mass in children and adolescents. The process of acquisition of bone mass starts at infancy and, during adolescence, the mineral content of the bone experiences a huge growth - compared to the rates at other stages of growth and child development.

From the perspective of primary prevention it is very important to have non-harmful methods at hand that evaluate bone mass in children given that, if the maximum bone mass is acquired during this period, the risk of suffering fractures during old age is reduced.

Conclusions

The research carried out at the University Hospital shows that, with both techniques for the measurement of bone mass, patients show values inferior to that of healthy children and adolescents. Comparing both techniques, it was observed that, paradoxically, osteosonography is a more suitable technique for the measurement of bone mass in those children and adolescents who have a body composition that is normal for their age, sex and puberal development. “It could be, nevertheless, a complementary method for monitoring the evolution of bone disorder in these patients and thus avoid tests that use radiation, although the DEXA continues to be the reference technique”.

Genetic involvement

The research also studied those determinant factors that may regulate the acquisition of bone mass. To this end, the Pediatrics Laboratory was the centre for the analysis of several polymorphisms of the vitamin D receptor genes, the collagen I-alfa-1 gene and the oestrogens receptor genes that are involved in determining bone mass.

The genetic markers for bone mass can help and identify patients who, because of their genetic make-up, are more prone to getting osteopenia and, in those cases of anorexia nerviosa thereby, may cause more severe complications in the osseous system.

Current treatments do not restore totally the lost bone mass and so, at least, one has to ensure an adequate ingestion of calcium and vitamin D from the outset of the illness.

Garazi Andonegi | alfa
Further information:
http://www.basqueresearch.com
http://www.elhuyar.com

More articles from Health and Medicine:

nachricht Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University

nachricht Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>