Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Hold the stuffing: Low-glycemic diet may help keep weight off

24.11.2004


Dieters have higher metabolism, feel less hungry

Preliminary data from Children’s Hospital Boston and Brigham and Women’s Hospital, published in the November 24 JAMA, suggest that weight-loss diets may be more effective when dieters seek to reduce glycemic load – the amount their blood glucose rises after a meal – rather than limit fat intake. The findings indicate that a low-glycemic diet may overcome the body’s natural tendency to slow metabolism and turn on hunger cues to "make up" the missing calories.

The low-glycemic-load (low-GL) diet reduces carbohydrates that are rapidly digested and that raise blood sugar and insulin to high levels -- such as white bread, refined breakfast cereals, and concentrated sugars. Instead, it emphasizes carbohydrates that release sugar more slowly, including whole grains, most fruits, vegetables, nuts, and legumes. "Our data suggest that the type of calories consumed – independent of the amount – can alter metabolic rate," says Dr. David Ludwig, director of the Optimal Weight for Life (OWL) obesity program at Children’s Hospital Boston and the study’s senior investigator. "That hasn’t been shown before. The idea that ’a calorie is a calorie is a calorie’ doesn’t really explain why conventional weight-loss diets usually don’t work for more than a few months."



Ludwig and colleagues randomized 46 overweight or obese adults aged 18 to 40 to consume one of two diets: a standard low-fat diet or a low-GL diet. Both diets provided approximately 1500 calories/day and were designed to produce a 10% weight loss in 6 to 10 weeks. However, the low-GL diet was higher in fat and made various carbohydrate substitutions, such as steel-cut oats instead of instant oatmeal, blueberries instead of raisins, and cracked-wheat bread instead of tortilla chips.

The 39 subjects who remained in the study succeeded in losing about 10% of their initial body weight. The low-GL dieters had smaller decreases in resting energy expenditure (averaging 96 kcal/day, or 5.9%) than the low-fat dieters (averaging 176 kcal/day, or 10.6%), meaning their metabolism did not slow as much. They also reported less hunger each day while on their diets.

"Almost anyone can lose weight in the short term – very few keep it off in the long term," says Ludwig. "That’s given rise to the notion that the body has a ’setpoint’ – and that when you diet, internal mechanisms work to restore your weight to that setpoint. A low-GL diet may work better with these internal biological responses to create the greatest likelihood of long-term weight loss."

Confirming other research, Ludwig’s team also found that the low-GL group had significantly greater improvements in insulin resistance (a risk factor for diabetes) and serum triglyceride and C-reactive protein levels (risk factors for cardiovascular disease). They now have a long-term study, in a larger group of subjects, to see if people on the low-GL diet can indeed keep off the lost pounds.

Dr. Mark Pereira of the Children’s Hospital Boston Department of Medicine (now at the University of Minnesota) was first author on the study.

Children’s Hospital Boston is recruiting adults for a large-scale, 18-month study of the low-GL diet. Subjects will receive comprehensive dietary and behavioral counseling in individual and group sessions that will enable them to put low-GL diets into effect. Subjects must be overweight, 18 to 35 years old, and motivated to attend weekly sessions for four months. People interested in enrolling should contact Erica Garcia-Lago at 617-355-2500.

Bess Andrews | EurekAlert!
Further information:
http://www.childrenshospital.org

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>