Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Study may lead to new means of increasing effectiveness of existing cancer treatments


Mount Sinai researchers identify a new mechanism that contributes to the development of some breast and ovarian cancers

Researchers at Mount Sinai School of Medicine have discovered a new mechanism of activation of a pathway known to be implicated in many cancers. Additionally, the researchers found that when this mechanism is blocked cells may become more sensitive to radiation and chemotherapeutic agents, thus making them easier to destroy. The research was published in the November issue of Cancer Cell.

The researchers investigated the Wnt pathway, which is known to be integral to regulation of cell differentiation – the process by which a stem cell develops into a specific type of cell. Once differentiated, cell proliferation is limited. When activated the Wnt pathway tells cells not to differentiate allowing them to grow unchecked, which can lead to development of a cancer.

Drs. Anna Bafico, Stuart Aaronson and colleagues at Mount Sinai School of Medicine discovered that in some breast, ovarian and colon cancer cells this pathway becomes active through triggering of a receptor on the surface of the cell. So, the cell can stimulate itself, remain in an undifferentiated state and continue to proliferate. Furthermore, they discovered that the pathway can be shut off at the cell surface by compounds that block the receptor. Once turned off, such cancer cells become more sensitive to agents that induce cell death.

While it was previously known that the Wnt pathway is involved in almost all cases of colon cancer and in some ovarian, and skin cancers, this study was the first to implicate this pathway in breast cancer and to identify this mechanism in human tumor cells. "An increasing number of cancer therapeutic agents are being developed to block pathways activated by interactions at the cell surface," said Dr. Aaronson, Professor and Chairman of Oncological Sciences at Mount Sinai School of Medicine. "This research provides a novel target to interfere with a pathway that is implicated in many cancer types."

"Selectively interfering in this pathway in cancer cells with this mechanism may make them more sensitive to existing treatments," said Dr. Bafico, Assistant Professor of Oncological Sciences at Mount Sinai School of Medicine.

Mount Sinai Press Office | EurekAlert!
Further information:

More articles from Health and Medicine:

nachricht NIH scientists describe potential antibody treatment for multidrug-resistant K. pneumoniae
14.03.2018 | NIH/National Institute of Allergy and Infectious Diseases

nachricht Researchers identify key step in viral replication
13.03.2018 | University of Pittsburgh Schools of the Health Sciences

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Locomotion control with photopigments

Researchers from Göttingen University discover additional function of opsins

Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...

Im Focus: Surveying the Arctic: Tracking down carbon particles

Researchers embark on aerial campaign over Northeast Greenland

On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...

Im Focus: Unique Insights into the Antarctic Ice Shelf System

Data collected on ocean-ice interactions in the little-researched regions of the far south

The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...

Im Focus: ILA 2018: Laser alternative to hexavalent chromium coating

At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.

When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...

Im Focus: Radar for navigation support from autonomous flying drones

At the ILA Berlin, hall 4, booth 202, Fraunhofer FHR will present two radar sensors for navigation support of drones. The sensors are valuable components in the implementation of autonomous flying drones: they function as obstacle detectors to prevent collisions. Radar sensors also operate reliably in restricted visibility, e.g. in foggy or dusty conditions. Due to their ability to measure distances with high precision, the radar sensors can also be used as altimeters when other sources of information such as barometers or GPS are not available or cannot operate optimally.

Drones play an increasingly important role in the area of logistics and services. Well-known logistic companies place great hope in these compact, aerial...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

Ultrafast Wireless and Chip Design at the DATE Conference in Dresden

16.03.2018 | Event News

International Tinnitus Conference of the Tinnitus Research Initiative in Regensburg

13.03.2018 | Event News

International Virtual Reality Conference “IEEE VR 2018” comes to Reutlingen, Germany

08.03.2018 | Event News

Latest News

Wandering greenhouse gas

16.03.2018 | Earth Sciences

'Frequency combs' ID chemicals within the mid-infrared spectral region

16.03.2018 | Physics and Astronomy

Biologists unravel another mystery of what makes DNA go 'loopy'

16.03.2018 | Life Sciences

Science & Research
Overview of more VideoLinks >>>