Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study may lead to new means of increasing effectiveness of existing cancer treatments

23.11.2004


Mount Sinai researchers identify a new mechanism that contributes to the development of some breast and ovarian cancers



Researchers at Mount Sinai School of Medicine have discovered a new mechanism of activation of a pathway known to be implicated in many cancers. Additionally, the researchers found that when this mechanism is blocked cells may become more sensitive to radiation and chemotherapeutic agents, thus making them easier to destroy. The research was published in the November issue of Cancer Cell.

The researchers investigated the Wnt pathway, which is known to be integral to regulation of cell differentiation – the process by which a stem cell develops into a specific type of cell. Once differentiated, cell proliferation is limited. When activated the Wnt pathway tells cells not to differentiate allowing them to grow unchecked, which can lead to development of a cancer.


Drs. Anna Bafico, Stuart Aaronson and colleagues at Mount Sinai School of Medicine discovered that in some breast, ovarian and colon cancer cells this pathway becomes active through triggering of a receptor on the surface of the cell. So, the cell can stimulate itself, remain in an undifferentiated state and continue to proliferate. Furthermore, they discovered that the pathway can be shut off at the cell surface by compounds that block the receptor. Once turned off, such cancer cells become more sensitive to agents that induce cell death.

While it was previously known that the Wnt pathway is involved in almost all cases of colon cancer and in some ovarian, and skin cancers, this study was the first to implicate this pathway in breast cancer and to identify this mechanism in human tumor cells. "An increasing number of cancer therapeutic agents are being developed to block pathways activated by interactions at the cell surface," said Dr. Aaronson, Professor and Chairman of Oncological Sciences at Mount Sinai School of Medicine. "This research provides a novel target to interfere with a pathway that is implicated in many cancer types."

"Selectively interfering in this pathway in cancer cells with this mechanism may make them more sensitive to existing treatments," said Dr. Bafico, Assistant Professor of Oncological Sciences at Mount Sinai School of Medicine.

Mount Sinai Press Office | EurekAlert!
Further information:
http://www.mssm.edu

More articles from Health and Medicine:

nachricht Vanishing capillaries
23.03.2017 | Technische Universität München

nachricht How prenatal maternal infections may affect genetic factors in Autism spectrum disorder
22.03.2017 | University of California - San Diego

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

When Air is in Short Supply - Shedding light on plant stress reactions when oxygen runs short

23.03.2017 | Life Sciences

Researchers use light to remotely control curvature of plastics

23.03.2017 | Power and Electrical Engineering

Sea ice extent sinks to record lows at both poles

23.03.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>