Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Loyola study shows drug-coated stent induces less inflammation than bare metal stent


In the treatment of coronary artery disease, a sirolimus drug-coated stent causes less inflammation than bare metal stents, according to preliminary research presented at the American Heart Association annual meeting by Loyola University Health System, Maywood, Ill.

“Inflammatory response is a sign of advancing heart disease, so the less inflammation the better,” said lead author Dr. Fred Leya, professor of medicine/cardiology, Loyola University Chicago Stritch School of Medicine.

Stents are small stainless steel coils or scaffolds which are used to keep blood vessels open and maintain blood flow to the heart. The drug-coated stent reduces the risk of restenosis (renarrowing) of blood vessels after angioplasty, a common problem with earlier stents, where 30 percent of arteries renarrowed. “Many times with the earlier stents, tissue cells grew too much scar tissue, renarrowing the artery that the stent was supposed to widen,” said Leya, director, interventional cardiology and director, cardiac catherization lab at Loyola. Leya said that the FDA-approved stent produces immediate results. “It is especially appropriate for diabetics, because they have smaller arteries and thus a greater risk of restenosis of coronary vessels following angioplasty,” he said.

Participating in the inflammation study were 55 patients: 27 received the drug-coated stent; another 28 patients were treated with a bare-metal stent. Researchers, looking for inflammation markers, took blood samples at baseline, and at 12- to 24 hours and four- to six hours after the procedure. Results of the study shows that inflammatory response was substantially reduced among patients who received the drug eluting stent compared to the bare metal stent. The next step, Leya said, is to measure inflammatory markers at one-year.

The stent uses a polymer, which acts as a time-release mechanism over approximately 30-45 days, to deliver medication that inhibits excessive cell growth into lumen of the vessel. “The advantage of the drug used on this stent is that it does not kill the cells, it just inhibits their growth,” said Leya, noting that when cells die, thrombosis (blood clots) could result. According to Leya, the latest research shows that with the new stent, renarrowing occurs in only 5 percent to 7 percent of patients. “That is good news for the hundreds of thousands of people who may need angioplasty and a stent this year,” said Leya.

Presenting the study at the AHA meeting is Walter Jeske, PhD, associate professor, department of Thoracic and Cardiovascular Surgery, Loyola University Health System.

Co-authors of the study with Jeske are Gary Maszak, Tony DeMartini, Dr. Omer Iqbal, Dr. Leslie Cho, Dr. Bruce Lewis, Dr. Lowell Steen, Fred Leya and Jeanine M. Walenga, PhD, Loyola University Health System.

The American Heart Association meeting continues through November 10.

Joanne Swanson | EurekAlert!
Further information:

More articles from Health and Medicine:

nachricht Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg

nachricht New potential cancer treatment using microwaves to target deep tumors
12.10.2016 | University of Texas at Arlington

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>