Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Loyola study shows drug-coated stent induces less inflammation than bare metal stent

10.11.2004


In the treatment of coronary artery disease, a sirolimus drug-coated stent causes less inflammation than bare metal stents, according to preliminary research presented at the American Heart Association annual meeting by Loyola University Health System, Maywood, Ill.



“Inflammatory response is a sign of advancing heart disease, so the less inflammation the better,” said lead author Dr. Fred Leya, professor of medicine/cardiology, Loyola University Chicago Stritch School of Medicine.

Stents are small stainless steel coils or scaffolds which are used to keep blood vessels open and maintain blood flow to the heart. The drug-coated stent reduces the risk of restenosis (renarrowing) of blood vessels after angioplasty, a common problem with earlier stents, where 30 percent of arteries renarrowed. “Many times with the earlier stents, tissue cells grew too much scar tissue, renarrowing the artery that the stent was supposed to widen,” said Leya, director, interventional cardiology and director, cardiac catherization lab at Loyola. Leya said that the FDA-approved stent produces immediate results. “It is especially appropriate for diabetics, because they have smaller arteries and thus a greater risk of restenosis of coronary vessels following angioplasty,” he said.


Participating in the inflammation study were 55 patients: 27 received the drug-coated stent; another 28 patients were treated with a bare-metal stent. Researchers, looking for inflammation markers, took blood samples at baseline, and at 12- to 24 hours and four- to six hours after the procedure. Results of the study shows that inflammatory response was substantially reduced among patients who received the drug eluting stent compared to the bare metal stent. The next step, Leya said, is to measure inflammatory markers at one-year.

The stent uses a polymer, which acts as a time-release mechanism over approximately 30-45 days, to deliver medication that inhibits excessive cell growth into lumen of the vessel. “The advantage of the drug used on this stent is that it does not kill the cells, it just inhibits their growth,” said Leya, noting that when cells die, thrombosis (blood clots) could result. According to Leya, the latest research shows that with the new stent, renarrowing occurs in only 5 percent to 7 percent of patients. “That is good news for the hundreds of thousands of people who may need angioplasty and a stent this year,” said Leya.

Presenting the study at the AHA meeting is Walter Jeske, PhD, associate professor, department of Thoracic and Cardiovascular Surgery, Loyola University Health System.

Co-authors of the study with Jeske are Gary Maszak, Tony DeMartini, Dr. Omer Iqbal, Dr. Leslie Cho, Dr. Bruce Lewis, Dr. Lowell Steen, Fred Leya and Jeanine M. Walenga, PhD, Loyola University Health System.

The American Heart Association meeting continues through November 10.

Joanne Swanson | EurekAlert!
Further information:
http://www.lumc.edu
http://www.luhs.org

More articles from Health and Medicine:

nachricht Penn studies find promise for innovations in liquid biopsies
30.03.2017 | University of Pennsylvania School of Medicine

nachricht 'On-off switch' brings researchers a step closer to potential HIV vaccine
30.03.2017 | University of Nebraska-Lincoln

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

'On-off switch' brings researchers a step closer to potential HIV vaccine

30.03.2017 | Health and Medicine

Penn studies find promise for innovations in liquid biopsies

30.03.2017 | Health and Medicine

An LED-based device for imaging radiation induced skin damage

30.03.2017 | Medical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>