Cath lab procedure could replace major heart surgery in some patients
The Hospital of the University of Pennsylvania (HUP) is participating in a nationwide clinical trial of a new valve repair device that could replace major heart surgery in some patients. A tiny clip – delivered by a catheter and deployed in the heart to repair a malfunctioning and leaking mitral valve – is building a favorable safety and feasibility profile as the EVEREST Phase I clinical trial nears completion.
Severe mitral valve regurgitation (MR) is a debilitating condition that causes shortness of breath, fatigue and palpitations. In the United States, about 250,000 people develop significant MR each year, with almost 50,000 requiring surgery. The clip is designed to secure the valves leaflets near the center of the valve so that blood leakage is minimized and the heart pumps more efficiently. This new device could decrease a patients hospital stay, result in fewer complications, provide a quicker recovery time, and significantly reduce health care costs. "In my most recently treated patient, we utilized two clips to reduce his MR from severe to mild. It has been six months since his procedure, and he has no symptoms whatsoever," says Howard C. Herrmann, MD, Director of Interventional Cardiology & the Cardiac Catheterization Laboratory at Penn, and principal investigator for HUPs component of the EVEREST Trial.
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