Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Awards for two pieces of research on schizophrenia

03.11.2004


The Department of Psychiatry at the University Hospital of the University of Navarre has received two awards at the XVII Congress of the European College of Neuropsychcopharmacology, held recently in Stockholm.



The studies awarded deal with the final conclusions of research work carried out by the Department in the field of schizophrenia. They specifically studied the biological bases of the disorder using neuroimaging and genetic study techniques. “It is known that one of the functions observed altered in patients with this ailment is that of attention. We wanted to see, by means of neuroimaging techniques, which regions of the brain might be failing when a person carries out specific tasks which need evermore attention”, explained Dr. Felipe Ortuño, specialist in the Department of Psychiatry at the University Hospital and principal author if this work.

The study compared the cerebral images of 11 healthy people with 11 patients, all subjected to exercise that demanded increasing attention. Using PET with oxygen 15 and the SPM (Statistical Parametric Mapping) image analysis system, the authors came to the conclusion that patients with schizophrenia have a number of dysfunctional areas. It was seen that, in general, they are located in the frontal cortex, such as the anterior limbic cortex and parietal. But, in this research, the involvement of a new area was detected, the supplementary motor area. This is a region which comes into play when tasks of attention aimed at evaluating temporary stimuli are required. When a healthy person is involved in an attention-demanding task, this region is triggered, but in patients with this pathology, the region is not activated with the same intensity. Moreover, it has been observed that, if this function fails, other, superior, functions may also fail. This work has been accepted for publication for the upcoming issue of the prestigious magazine, Neuroimage.


The second work that received an award was part of the PhD thesis of Dr. Patricio Molero studying the genetic aspects of schizophrenia. The role of a gene in the etiology of the schizophrenia was studied; concretely, that of the catecol-o-methyltransferase (COMT) enzyme. The research was undertaken on a sample of 134 patients, wherein it was observed that there was a tendency of specific association of the Val genotype with schizophrenia. His other conclusion was that it would appear that this genotype is associated with a better response from treatment with neuroleptics

Schizophrenia

Schizophrenia is a serious mental disorder which appears in very early stages in life – typically in adolescence or at the beginning of adult life. It is an illness which affects many superior functions: thought (false beliefs appear as deliriums), sensoperception (hallucinations), emotions (appear increasingly deteriorated), willpower (initiative is lost), attention (more difficulty in paying attention) and personality deteriorates.

Since the 80s there have been great advances in understanding the origin of this disorder. In the brains of those with schizophrenia very subtle variations have been found – a very small decrease in the volume of the frontal cortex region (responsible for thought), in the limbic system region (responsible for emotions). Studies reveal that these alterations had been produced in early stages of intrauterine life. As a result, many studies, not only anatomopathological, but also with neuroimage techniques, genetics, etc., have been developed. For the future of this research an interdisciplinary approach is required to study the etiology, diagnosis, prognosis and treatment of the disorder.

Irati Kortabitarte | alfa
Further information:
http://www.basqueresearch.com
http://www.elhuyar.com

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

Physicists discover mechanism behind granular capillary effect

24.05.2017 | Physics and Astronomy

Measured for the first time: Direction of light waves changed by quantum effect

24.05.2017 | Physics and Astronomy

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>