Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Nicotine’s addictive hold increases when combined with other tobacco smoke chemicals

29.10.2004


Smoking cessation efforts could be improved by studying nicotine interactions with acetaldehyde, according to UCI tobacco use researchers



Acetaldehyde, one of the main chemical components of tobacco smoke, appears to increase the addictive properties of nicotine, according to animal studies conducted by the UC Irvine Transdisciplinary Tobacco Use Research Center (TTURC). In addition, the researchers found that adolescents are most vulnerable to the rewarding effects of the nicotine-acetaldehyde combination.

Study results appear in the online version of Neuropsychopharmacology.


Nicotine is the primary chemical in cigarette smoke that causes addiction, yet when tested in animal studies, the draw of nicotine alone appears to be relatively weak compared to other abused drugs. Surprised by this phenomenon, UCI researchers conducted a series of studies in rodents to determine whether nicotine may interact with some of the other 4,000 components of tobacco smoke to enhance addictiveness. “We chose to study acetaldehyde because it is a major component of tobacco smoke, present in a one-to-two ratio to nicotine,” said James Belluzzi, lead researcher and adjunct professor of pharmacology in the UCI College of Medicine. “Additionally, there is evidence that acetaldehyde may play a role in alcohol addiction.”

Belluzzi, researcher Ruihua Wang and Frances Leslie, professor of pharmacology and TTURC director, evaluated possible acetaldehyde and nicotine interactions in a rigorous self-administration test. Adolescent and adult male rats were tested in a procedure during which each nose poke by the rodents delivered acetaldehyde or nicotine, a combination of both drugs, or saline. Adolescent animals quickly learned to self-administer the nicotine-acetaldehyde combination significantly more than saline or either drug alone. Furthermore, young adolescents were more responsive to the drug combination than older adolescents.

When adult animals were tested in identical experiments, they did not self-administer the nicotine-acetaldehyde mixture or either drug alone at levels significantly higher than saline. Belluzzi and his team also used self-administration tests of cocaine to test the reliability of the novel self-administration procedure and to evaluate whether early adolescence was a period of enhanced vulnerability to other abused drugs. Although adolescent rats are more responsive to the nicotine-acetaldehyde mix than adult rats, the young rats were not more responsive to cocaine than adults. “Our latest findings suggest that the study of tobacco addiction, as well as the development of smoking cessation treatments, could be improved by studying the interactions of nicotine with other smoke components,” Leslie said.

Tom Vasich | EurekAlert!
Further information:
http://www.uci.edu

More articles from Health and Medicine:

nachricht Speed data for the brain’s navigation system
06.12.2016 | Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE)

nachricht Study suggests possible new target for treating and preventing Alzheimer's
02.12.2016 | Oregon Health & Science University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Predicting unpredictability: Information theory offers new way to read ice cores

07.12.2016 | Earth Sciences

Sea ice hit record lows in November

07.12.2016 | Earth Sciences

New material could lead to erasable and rewriteable optical chips

07.12.2016 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>