Researchers at the Medical Research Council (MRC) Cancer Cell Unit, Cambridge have gained an important new insight into the role of the breast cancer gene known as BRCA2. It appears to have a key function in cell division which needs to happen accurately for normal cell reproduction and repair, otherwise disease occurs. The findings are published today (29 Friday October 2004) in the journal Science.
Around 30 to 50 per cent of breast cancers that run in families are thought to occur because the BRCA2 gene is not working. People who inherit defective BRCA2 are not only more susceptible to breast cancer, but also have a higher risk of developing cancers of the ovary, pancreas and prostate. The researchers found that where there was a mutation in the BRCA2 gene, cells failed to divide accurately and acquired an incorrect number of chromosomes.*
The final critical step where cells divide is called cytokinesis. This is where a cell separates into two to create replicas of itself known as ‘daughter cells’. It is at this point that a full set of chromosomes is put together for each of the new cells. Any malfunction in this process can result in cells having too few or too many chromosomes or abnormalities, which have implications for disease. Since the discovery of the breast cancer susceptibility genes BRCA1 and BRCA2, researchers have sought to identify exactly why mutations in these genes lead to breast cancer. Understanding the role BRCA2 has in cell division and chromosome separation sheds light on this mechanism and what happens when it goes wrong.
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On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
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Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
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Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
17.10.2017 | Event News
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