Researchers at the Medical Research Council (MRC) Cancer Cell Unit, Cambridge have gained an important new insight into the role of the breast cancer gene known as BRCA2. It appears to have a key function in cell division which needs to happen accurately for normal cell reproduction and repair, otherwise disease occurs. The findings are published today (29 Friday October 2004) in the journal Science.
Around 30 to 50 per cent of breast cancers that run in families are thought to occur because the BRCA2 gene is not working. People who inherit defective BRCA2 are not only more susceptible to breast cancer, but also have a higher risk of developing cancers of the ovary, pancreas and prostate. The researchers found that where there was a mutation in the BRCA2 gene, cells failed to divide accurately and acquired an incorrect number of chromosomes.*
The final critical step where cells divide is called cytokinesis. This is where a cell separates into two to create replicas of itself known as ‘daughter cells’. It is at this point that a full set of chromosomes is put together for each of the new cells. Any malfunction in this process can result in cells having too few or too many chromosomes or abnormalities, which have implications for disease. Since the discovery of the breast cancer susceptibility genes BRCA1 and BRCA2, researchers have sought to identify exactly why mutations in these genes lead to breast cancer. Understanding the role BRCA2 has in cell division and chromosome separation sheds light on this mechanism and what happens when it goes wrong.
Resolving the mystery of preeclampsia
21.10.2016 | Universitätsklinikum Magdeburg
New potential cancer treatment using microwaves to target deep tumors
12.10.2016 | University of Texas at Arlington
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.
Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
21.10.2016 | Health and Medicine
21.10.2016 | Information Technology
21.10.2016 | Materials Sciences