Treating patients with advanced non-small cell lung cancer more aggressively by giving them higher doses of radiation helps keep the disease from spreading and allows some patients to live longer, according to a new study published in the November 1, 2004, issue of the International Journal of Radiation Oncology*Biology*Physics, the official journal of ASTRO, the American Society for Therapeutic Radiology and Oncology.
An estimated 45,000 to 50,000 people were diagnosed with locally advanced non-small cell lung cancer in 2003 with an expected five-year survival rate of only 10 to 20 percent, according to the study. Although adding chemotherapy can help some patients live longer, in general survival rates are very low, particularly in comparison to other cancers.
In the study, 72 patients with stage III (or advanced) non-small cell lung cancer were split into two groups and treated with different doses of three-dimensional conformal radiotherapy in addition to chemotherapy. Of the 37 patients in the first group treated with a low dose of radiation therapy, 61 percent of the patients saw their cancer spread during the first year. By the second year, 76 percent of the patients had suffered a relapse. In contrast, of the 35 patients in the second group who were treated with a higher dose of radiation therapy, 27 percent of patients saw their cancer come back within the first year and 47 percent had suffered a relapse by the second year.
Beth Bukata | EurekAlert!
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Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.
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Fiber-reinforced plastics (FRP) are frequently used in the aeronautic and automobile industry. However, the repair of workpieces made of these composite materials is often less profitable than exchanging the part. In order to increase the lifetime of FRP parts and to make them more eco-efficient, the Laser Zentrum Hannover e.V. (LZH) and the Apodius GmbH want to combine a new measuring device for fiber layer orientation with an innovative laser-based repair process.
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