Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Early reports of thrombosis after insertion of drug-eluting stent

22.10.2004


Authors of a research letter in this week’s issue of THE LANCET highlight how the use of drug-eluting stents (DES) may carry a risk of subsequent thrombosis if stenting is accompanied by a withdrawal of antiplatelet therapy.



More than 1•5 million people a year have stents implanted to improve coronary artery blood flow. A recently published pooled analysis of 11 trials (see Lancet 2004; 364: 583-91) suggested that DES—increasingly used in coronary angioplasty—have benefits over bare-metal stents (BMS) by reducing the need for later revascularisation and reducing the risk of cardiac events.

Patrick W Serruys (Erasmus Medical Center, Netherlands) and colleagues report four cases of angiographically-confirmed stent thrombosis that occurred around a year after elective implantation of polymer-based paxlitaxel-eluting or sirolimus-eluting stents; all four cases resulted in myocardial infarction (heart attack). All cases arose soon after antiplatelet therapy was interrupted.


Professor Serruys comments: “We report these cases to draw attention to a problem, with serious clinical implications, that might be under-reported. We suggest that the potential risk of stent occlusion should be considered when discontinuation of antiplatelet therapy is contemplated in patients with drug-eluting stents. As the use of drug-eluting stents becomes widespread, careful long-term follow-up of patients with such stents is needed to assess the true rate of late thrombosis.”

In an accompanying commentary (p 1466), Mark J Eisenberg (Jewish General Hospital/McGill University, Montreal, Canada) concludes: “…drug-eluting stents are so new that many health-care professionals are not aware of the critical need for prolonged and continuous antiplatelet therapy. Therefore, both patients and physicians should be sensitised to the possibility of late stent-thrombosis if antiplatelet therapy is interrupted. The case reports by McFadden and colleagues strongly and persuasively suggest that stent thrombosis might occur many months after the implantation of a drug-eluting stent if prolonged and continuous antiplatelet therapy is not maintained.”

Richard Lane | alfa
Further information:
http://www.lancet.com

More articles from Health and Medicine:

nachricht How cancer metastasis happens: Researchers reveal a key mechanism
19.01.2018 | Weill Cornell Medicine

nachricht Researchers identify new way to unmask melanoma cells to the immune system
17.01.2018 | Duke University Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Thanks for the memory: NIST takes a deep look at memristors

22.01.2018 | Materials Sciences

Radioactivity from oil and gas wastewater persists in Pennsylvania stream sediments

22.01.2018 | Earth Sciences

Saarland University bioinformaticians compute gene sequences inherited from each parent

22.01.2018 | Life Sciences

VideoLinks Wissenschaft & Forschung
Overview of more VideoLinks >>>