Occlusion of the basilar artery (BAO) is a relatively infrequent but the most catastrophic form of ischemic stroke with a dismal natural course, carrying from 85 to almost 95 % mortality. Complete BAO precipitates a sudden or gradually worsening clinical syndrome with bilateral motor weaknesses, visual or speech disturbances, deficits in motor coordination and balance, and often leads to reduced consciousness. The most devastating end-point is the locked-in state, in which the patient is conscious but can move only his or her eyes. Many stroke centers have in the past used invasive, intra-arterial thrombolysis to recanalize BAO, which is limited to hospitals with immediate invasive radiologist service.
Previous reports have advocated thrombolytics delivered with invasive endovascular approach to the occlusion site, but even a short delay in the onset of therapy has been reported to be the single most critical factor affecting outcome. Due to unacceptable treatment delays, Finnish neurologists led by Docent Perttu J. Lindsberg and Professor Markku Kaste at Helsinki University Central Hospital reverted from intra-arterial approach to noninvasive, intravenous delivery of alteplase, a protocol used more commonly in anterior circulation strokes. The results of this study were published 20.10.2004 in JAMA (Journal of American Medical Association).
Since 1995, 50 patients with proven BAO were treated in Helsinki according to institutional thrombolysis protocol. By 3 months, 20 patients (40%) died, while 12 patients (24%) reached independence in activities of daily life. On the long-term, patients with recanalized basilar artery and fair outcome continued to improve functionally and survivors reported unexpectedly satisfactory ratings of the quality of their daily life.
Paivi Lehtinen | alfa
Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University
Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München
In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".
Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
23.02.2017 | Physics and Astronomy
23.02.2017 | Earth Sciences
23.02.2017 | Life Sciences