Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Men with prostate permalignant lesions have increased likelyhood of invasive prostate cancer

19.10.2004


In the largest known study of its kind, scientists have confirmed that men with high grade prostatic intraepithelial neoplasia or PIN, characterized by abnormal cells in the lining of prostate ducts, are at high risk for invasive prostate cancer. The study, presented today at the American Association for Cancer Research Third Annual International Conference on Frontiers in Cancer Prevention Research, showed that about one in three men with high grade PIN are at high risk for prostate cancer within a year of detection and should be closely monitored for disease progression.



"This study confirms that the increased risk factor associated with high-grade PIN is real and not just a coincidence," said Dr. Mitchell S. Steiner, chief executive officer with GTx, Inc. "The next step is to develop an effective therapy for treating high grade PIN, before prostate cancer has a chance to take root. We know that there is a measurable window of opportunity for treatment before the cancer appears. "We must take advantage of that opportunity as a key step toward prostate cancer prevention."

In this prospectively designed study, some 109 men with high-grade PIN and no prostate cancer at baseline were analyzed. In addition to the baseline biopsy, patients were re-biopsied at six and 12 months to test for the presence of prostate cancer. Results demonstrate that within one year, men in the placebo group had a 31.4 percent risk of being diagnosed with prostate cancer.


A sub-set analysis of the placebo patients in a year long, chemopreventive toremifene study, which was also presented at the AACR meeting here, confirmed that men with high-grade PIN have an increased, cumulative risk of being diagnosed with prostate cancer after one year. According to the National Cancer Institute, prostate cancer is the most commonly diagnosed cancer in America among men. With an estimated 220,000 new cases diagnosed each year, one in every five men will get prostate cancer during his lifetime. African-American men are at special risk for the disease. In fact, the incidence rate in African-Americans is 60 percent higher than that in white males and double the mortality rate. An estimated 29,900 American men lose their lives to prostate cancer each year.

Angela DeCicco | EurekAlert!
Further information:
http://www.aacr.org

More articles from Health and Medicine:

nachricht The end of pneumonia? New vaccine offers hope
23.10.2017 | University at Buffalo

nachricht Scientists track ovarian cancers to site of origin: Fallopian tubes
23.10.2017 | Johns Hopkins Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Salmonella as a tumour medication

HZI researchers developed a bacterial strain that can be used in cancer therapy

Salmonellae are dangerous pathogens that enter the body via contaminated food and can cause severe infections. But these bacteria are also known to target...

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

3rd Symposium on Driving Simulation

23.10.2017 | Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

 
Latest News

Microfluidics probe 'cholesterol' of the oil industry

23.10.2017 | Life Sciences

Gamma rays will reach beyond the limits of light

23.10.2017 | Physics and Astronomy

The end of pneumonia? New vaccine offers hope

23.10.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>