Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Nevirapine is better than efavirenz at raising ’good’ cholesterol

19.10.2004


Two of the most commonly prescribed drugs for treating HIV (antiretroviral drugs)--nevirapine and efavirenz--can both raise levels of the "good type" of cholesterol (HDL cholesterol), but nevirapine raises it higher than efavirenz, according to a new study by van Leth and colleagues published in the launch issue of PLoS Medicine. "These data suggest that nevirapine may be preferable to efavirenz in HIV-infected adults who have increased cardiovascular risk," says Andrew Carr, an HIV specialist at St. Vincent’s Hospital in Sydney, Australia, who was not involved in the study. Cardiovascular risk factors include high blood pressure, diabetes, and smoking, which put patients at higher risk of heart disease and stroke.




However, perceived cardiovascular risk is only one factor that would affect the choice between these two drugs, notes Carr. Efavirenz is thought to be marginally better than nevirapine at keeping HIV infection under control; efavirenz is also advantageous because patients only need to take it once a day, whereas nevirapine must be taken twice daily. The new study "moves clinicians and patients away from ’one-size-fits-all antiretroviral therapy,’" says Carr, allowing them to weigh up the different advantages and disadvantages of each drug.

In the study, the researchers compared the cholesterol levels in 417 patients with HIV who were taking nevirapine against 289 patients who were taking efavirenz. None of the patients had been on any antiretroviral drugs before. Patients taking nevirapine had a significantly larger increase in HDL cholesterol compared with patients taking efavirenz.


Although the increase was higher with nevirapine, this does not prove that nevirapine is better at reducing the risk of heart disease and strokes, says Carr. The researchers did not look at the risk of these diseases in their study.

Praphan Phanuphak, of the Thai Red Cross AIDS Research Center in Bangkok, Thailand, who was one of the authors of the study, says that the findings are particularly important for treating HIV in the developing world. "Nevirapine is much cheaper, particularly in developing countries where generic drugs are available," says Phanupak. "In many developing countries, nevirapine is incorporated in fixed dose combination with other drugs such as stavudine and lamivudine which costs only US$1 per day."

Paul Ocampo | EurekAlert!
Further information:
http://www.plos.org
http://www.amc.uva.nl

More articles from Health and Medicine:

nachricht New malaria analysis method reveals disease severity in minutes
14.08.2017 | University of British Columbia

nachricht New type of blood cells work as indicators of autoimmunity
14.08.2017 | Instituto de Medicina Molecular

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

Im Focus: Scientists improve forecast of increasing hazard on Ecuadorian volcano

Researchers from the University of Miami (UM) Rosenstiel School of Marine and Atmospheric Science, the Italian Space Agency (ASI), and the Instituto Geofisico--Escuela Politecnica Nacional (IGEPN) of Ecuador, showed an increasing volcanic danger on Cotopaxi in Ecuador using a powerful technique known as Interferometric Synthetic Aperture Radar (InSAR).

The Andes region in which Cotopaxi volcano is located is known to contain some of the world's most serious volcanic hazard. A mid- to large-size eruption has...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

New thruster design increases efficiency for future spaceflight

16.08.2017 | Physics and Astronomy

Transporting spin: A graphene and boron nitride heterostructure creates large spin signals

16.08.2017 | Materials Sciences

A new method for the 3-D printing of living tissues

16.08.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>