Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

U-M professor to test flu shot and nasal spray flu vaccine side by side

14.10.2004


A University of Michigan influenza expert is beginning a three-year direct comparison of the effectiveness of flu shots versus nasal spray flu vaccine.

Flu shots have been around since World War II, and the Centers for Disease Control and Prevention has long recommended shots as a way to prevent influenza in the elderly. The approval of a new nasal spray vaccine begs the question whether those looking to stave off the flu should stick with the tried and true injection or switch to the nasal spray.

"We really don’t know whether one is superior to the other in adults," said Arnold Monto, professor of epidemiology at the U-M School of Public Health and a life-long researcher on cold and flu. "We want to be able to say whether there is an advantage in protection."



Both the injectable flu shot and the inhaled nasal spray use three different strains of flu every year as their base. A group of leading scientists uses disease surveillance to predict which types of flu are most likely to become a problem in the United States, and vaccines produced annually protect against those types.

The flu shot uses killed virus, meaning it is formulated using flu virus that’s killed and injected into the patient to encourage a low-level immune response. Triggering this response helps the patient’s body fight off later encounters with those strains of flu.

The nasal spray uses live but weakened cold-adapted virus. It is specially grown so that it can survive in the cooler conditions of the nose, but not in the warmer lungs, where flu takes hold.

Monto wants to understand the different ways humans respond to killed or live virus vaccines. For example, he already knows that people who get the nasal spray sometimes might develop fewer antibodies---the body’s front-line warriors called up for duty in the presence of a threat---than people who get the shot, but they might still be protected. what he doesn’t understand yet is whether other substances developed in response to the nasal spray might somehow be more effective.

The study will enroll about 2,000 people at sites in Ann Arbor, Livonia and Mount Pleasant, Mich. They will receive a shot, nasal spray or a placebo. Monto’s team will monitor the participants to see who gets the flu, and compare the effectiveness of the two vaccines to each other as well as to the rates of disease in the unvaccinated group. Participants will give blood samples and scientists will look at antibody levels for the three groups.

FluMist, the nasal spray flu vaccine, is based on technology developed by Hunein "John" Maassab, professor emeritus of epidemiology at the U-M School of Public Health. U-M licensed the technology to MedImmune Inc., and receives royalty payments in addition to holding a small equity stake in the company. The U.S. Food and Drug Administration is monitoring conduct of the study, which is supported by a $3.6 million, three-year grant from the National Institutes of Health.

The study will only include adults ages 18-46. FluMist is approved for adults ages 18-49; enrolling the first year at age 46 allows patients to finish the full three-year study and still be in the approved age group to receive FluMist.

According to the Centers for Disease Control and Prevention, between 5- 20 percent of U.S. residents will get influenza each year; an estimated 114,000 will be admitted to the hospital and 36,000 people will die as a result of influenza infection each year in the United States.

Monto’s study aims to determine how the vaccines work to control annual influenza outbreaks and to gather valuable information for influenza pandemic planning. An influenza pandemic is a global outbreak of influenza, which occurs when a new influenza A virus emerges among people, spreads, and causes disease worldwide. Past influenza pandemics have resulted in widespread illness, increased mortality, social disruption and economic loss.

Colleen Newvine | EurekAlert!
Further information:
http://www.umich.edu

More articles from Health and Medicine:

nachricht Researchers release the brakes on the immune system
18.10.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Norovirus evades immune system by hiding out in rare gut cells
12.10.2017 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Terahertz spectroscopy goes nano

20.10.2017 | Information Technology

Strange but true: Turning a material upside down can sometimes make it softer

20.10.2017 | Materials Sciences

NRL clarifies valley polarization for electronic and optoelectronic technologies

20.10.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>