Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Insulin resistance in teens raises high blood pressure risk as adults

11.10.2004


Teenagers whose bodies have a decreased response to insulin might face an increased risk of high blood pressure as adults, according to a large, long-term study reported at the American Heart Association’s 58th Annual High Blood Pressure Research Conference.



Insulin is a hormone that regulates glucose, a blood sugar. Insulin resistance occurs when the body begins to lose its ability to regulate glucose, which can lead to diabetes.

Researchers assessed insulin resistance in teens over five years and found the condition was associated with higher systolic blood pressure. Systolic pressure is the top number in a blood pressure reading; it measures the pressure in arteries when the heart contracts. Insulin resistance was also linked to obesity. Statistical analysis showed that insulin resistance was independently associated, to lesser extent, with unfavorable changes in cholesterol levels and other blood fats.


"The results indicate that one of the keys to preventing high blood pressure is to start thinking about it in childhood," said Alan Sinaiko, M.D., professor of pediatrics at the University of Minnesota in Minneapolis. "If insulin resistance in childhood is related to risk factors in adulthood, we ought to be thinking about this problem at an early age. By the time people are in their 20s and 30s, a lot of the risk is already set, and we are treating the disease instead of preventing it."

The study not only documents the independent association of insulin resistance to heart risk factors, but also provides information about the origin of the condition, Sinaiko said. "We know that insulin resistance exists, but we don’t know a lot about the insulin resistance syndrome and how it develops," he said. "This study shows that insulin resistance is present at a very young age. Even though children don’t have the same degree of heart risk factors as adults, the findings suggest that insulin resistance has an early influence on what happens to people as adults."

The findings came from a study that began 10 years ago, involving 357 children whose average age was 13 at the time. Over the next 5.5 years, each of the children had evaluations of their body’s response to insulin three times (enrollment, age 15 and 19).

Doctors evaluated sensitivity to insulin with a technique called the euglycemic clamp. The test involves infusing a small amount of insulin into the blood for three hours. Simultaneously, glucose is infused through another vein. The test was designed to maintain blood sugar at a fairly normal level of 100 milligrams per deciliter (mg/dL).

A small amount of glucose to maintain blood sugar levels indicates insulin resistance. Increasing amounts of glucose indicated insulin sensitivity, the desired response.

At age 13, none of the children had hypertension (high blood pressure), and the average blood pressure for the study group was 109/55 millimeters of mercury (mm Hg) in 198 boys and 106/58 mm Hg in 159 girls.

At age 19, systolic blood pressure increased by 0.42 mm Hg for each unit of insulin resistance at age 13, and it increased by 0.81 mm Hg for each unit increase in BMI. Triglycerides increased by 0.88 mg/dL for each unit increase in insulin resistance, and by 3.1 mg/dL per each unit of BMI (body mass index, a measure of fatness) at age 13. HDL cholesterol increased by 0.20 mg/dL for each unit increase in insulin resistance, and 0.32 for each unit increase in BMI.

The effects of insulin resistance on systolic blood pressure were independent of those related to BMI. "There is no question that obesity in some people is significantly related to insulin resistance," Sinaiko said. "What we’re showing is that insulin resistance has an effect on systolic blood pressure that is independent of fatness and obesity. Strategies designed to reduce childhood obesity to prevent cardiovascular risk and type 2 diabetes may need to be complemented by treatment of insulin resistance in at-risk people."

Co-authors are David R. Jacobs Jr., Ph.D.; Julia Steinberger, M.D.; and Antoinette Moran, M.D.

Statements and conclusions of study authors that are published in the American Heart Association scientific journals are solely those of the study authors and do not necessarily reflect association policy or position. The American Heart Association makes no representation or warranty as to their accuracy or reliability.

Maggie Francis | EurekAlert!
Further information:
http://www.heart.org

More articles from Health and Medicine:

nachricht Researchers release the brakes on the immune system
18.10.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Norovirus evades immune system by hiding out in rare gut cells
12.10.2017 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Osaka university researchers make the slipperiest surfaces adhesive

18.10.2017 | Materials Sciences

Space radiation won't stop NASA's human exploration

18.10.2017 | Physics and Astronomy

Los Alamos researchers and supercomputers help interpret the latest LIGO findings

18.10.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>