Two types of thyroid cancer that are closely related and sometimes difficult to distinguish can be readily identified by differences in only a few genes, new research shows.
The study, by researchers at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, used microarray analysis to show that papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC) differ in the expression of only four or five genes.
Distinguishing between the two cancers is important because the malignancies behave differently and require different treatment. The research should also help scientists better understand the origins of the two diseases. The study is published in the a recent issue of the Journal of Clinical Oncology. “This finding suggests a potentially very useful diagnostic aid in those rare instances where the pathologist cannot distinguish between FTC and PTC,” says study leader Charis Eng, the Dorothy E. Klotz Chair of Cancer Research and director of OSU’s clinical cancer genetics program.
Darrell E. Ward | EurekAlert!
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