Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New protocols in kidney- pancreas transplantation produces better results for patients

29.09.2004


Patients now living insulin free and off dialysis

Due to refined surgical techniques and advances in anti-rejection therapy, transplant surgeons at the University of Pittsburgh’s Thomas E. Starzl Transplantation Institute (STI) are able to successfully perform a higher volume of kidney-pancreas transplants – more than 22 kidney-pancreas transplants in the past three months – which yields a shorter wait time on the transplant list, a better graft survival and quicker recovery. "People need to be more aware of our services, in particular, diabetic patients with end-stage renal disease," said Ngoc Thai, M.D., Ph.D., assistant professor of surgery and director of pancreas transplantation at STI.

Another advance in the field of kidney-pancreas transplantation is the use of the drug campath – a powerful immunosuppressant that depletes T and B cells – the cells that may cause rejection of the new organ. Only one dose is given before the transplant surgery. Because of its potency, a single dose of campath can be given to treat active rejection as well. There is little risk above and beyond the usual side-effects of immunosuppression. The advantage is that patients only need to take the anti-rejection medication FK after surgery, as opposed to a combination of FK, MMF and steroids. Currently, researchers at STI are one of a few transplant centers in the United States participating in a clinical trial to study the advantages of campath therapy for kidney-pancreas transplant recipients.



The pancreas is a five-inch organ that is located behind the stomach. One function of the pancreas is to produce enzymes that aid in the digestion of food. It also produces insulin, which is essential for life because it regulates the use of blood sugar throughout the body. In patients with diabetes, the pancreas stops producing insulin and the organ may shut down, eventually requiring a transplant. This stress also can affect the kidneys, so often a patient in need of a pancreas often will need a new kidney as well.

The three procedures used in these patients include a kidney from either a living or cadaveric donor and eventually a cadaveric pancreas at a later date; a simultaneous kidney-pancreas transplant; or a pancreas transplant alone. According to the United Network for Organ Sharing (UNOS) there are currently 2,420 people in the United States waiting for a kidney-pancreas transplant and 1,645 people waiting for a pancreas transplant alone. Currently at UPMC, there are roughly 20 people waiting for a combined kidney-pancreas transplant and approximately 20 people waiting for a pancreas transplant alone.

UPMC transplant programs comprise the world’s largest and busiest, where surgeons perform more types of organ transplants than at any other institution. On average, a transplant is performed every 12 hours at UPMC Montefiore or Children’s Hospital of Pittsburgh. Since 1981, more than 12,000 transplants have been performed, a single-center experience that is unmatched by any other program in the world. These transplants include liver, kidney, pancreas, small bowel, liver/small bowel, heart, heart/lung, double-lung, single-lung and multiple-organ transplants.

Pittsburgh’s transplant programs are internationally renowned for having had far-reaching influence on the entire field. UPMC researchers and surgeons have made many of transplantation’s most important advances. In recent years, clinical and research programs have involved novel approaches to induce tolerance of transplanted organs, and pioneering efforts to explore alternative sources of human organs, such as organs from animal donors or artificial organs.

Maureen McGaffin | EurekAlert!
Further information:
http://www.upmc.edu

More articles from Health and Medicine:

nachricht Researchers release the brakes on the immune system
18.10.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Norovirus evades immune system by hiding out in rare gut cells
12.10.2017 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Terahertz spectroscopy goes nano

20.10.2017 | Information Technology

Strange but true: Turning a material upside down can sometimes make it softer

20.10.2017 | Materials Sciences

NRL clarifies valley polarization for electronic and optoelectronic technologies

20.10.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>