The scientist who identified the target for several drugs used to treat sleeping sickness and Chagas disease has just discovered that antimonial drugs used to treat Leishmaniasis attack the same target.
And, he is "highly optimistic" that research on the parasite molecule "trypanothione", and enzymes that use trypanothione, will lead to a drug that will cure all three tropical diseases.
Professor Alan Fairlamb at the University of Dundee has worked out how the sulphur containing compound trypanothione allows these parasites to fend off free radicals and other toxic oxidants produced by the immune system of the infected patient. Antimonial drugs effectively neutralise the leishmania parasites antioxidant defence system, allowing the patient to clear the infection. This may explain why so many patients co-infected with HIV fail to respond well to treatment with antimonials.
Jenny Marra | alfa
Nanoparticles as a Solution against Antibiotic Resistance?
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Plasmonic biosensors enable development of new easy-to-use health tests
14.12.2017 | Aalto University
DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.
Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
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