Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Oral Amoxicillin Could be Future Treatment for Children with Pneumonia

27.09.2004


Pneumonia—one of the world’s deadliest diseases for young children in developing countries—could be treatable by the oral antibiotic amoxicillin rather than injectable penicillin, with implications for better health outcomes and reduced costs, conclude authors of an international study in this week’s issue of THE LANCET.



Nearly 2 million children under 5 years of age die every year in developing countries from respiratory diseases such as pneumonia. Penicillin given by injection is the recommended treatment for severe pneumonia defined by the World Health Organisation (lower chest indrawing). It is proposed that oral amoxicillin could reduce referral, admission, and treatment costs if it can be proven to be as effective as injectable penicillin.

In a randomised trial done in eight developing countries in Africa, Asia, and South America, around 1700 children aged between 3 months and 5 years admitted to tertiary care centres were randomly allocated to receive either injectable penicillin or oral amoxicillin. The main outcome measure of the study—treatment failure after 48 hours— was the same in both groups (19%). There was also no difference in outcome between the two groups at 5-day and 14-day follow-up.


Investigator Shamin Qazi (WHO) comments: “Our findings have several important beneficial implications if applied as public-health policy; oral amoxicillin will reduce (1) the risk of needle-associated complications such as needle-borne infections; (2) the need for referral or admission; (3) treatment administration costs; and (4) transport, food, and lost income costs for the family”.

In an accompanying commentary (p 1104), Keith P Klugman (Emory University, Atlanta, USA) states: “The researchers point out the benefits that accrue from this observation—ie, diminished risk associated with the use of needles, decreased cost to the health system, and indeed reduced cost to the patients’ families. The investigators also suggest that the results could reduce the perceived need for hospitalisation of children with severe pneumonia. Here, the evidence is less clear. All the children enrolled in this study were initially admitted to hospital. Therefore, they also received the probable benefits of medical attention, nutritional support, and supplemental oxygen therapy...nonetheless, this study supports the idea of further work to demonstrate the safety and efficacy of oral antibiotics for severe pneumonia therapy in outpatient settings, perhaps together with improved access to nutritional support and oxygen.”

| newswise
Further information:
http://www.thelancet.com

More articles from Health and Medicine:

nachricht Hot cars can hit deadly temperatures in as little as one hour
24.05.2018 | Arizona State University

nachricht 3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Could a particle accelerator using laser-driven implosion become a reality?

24.05.2018 | Physics and Astronomy

Hot cars can hit deadly temperatures in as little as one hour

24.05.2018 | Health and Medicine

Complementing conventional antibiotics

24.05.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>