Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Asthmatic Patients with Sinusitis More Likely to Have Nasal Polyps

20.09.2004


Some 37 million Americans suffer from sinusitis; some of those patients are unfortunate enough to also have asthma, an inflammatory disease of the lungs characterized by reversible airway obstruction. The Centers for Disease Control (CDC) estimates that more than 15 million Americans have this disorder. The association between asthma and rhinosinusitis has long been established. While this relationship is unclear, molecular research is now focusing on whether asthma and rhinosinusitis are likely upper and lower airway manifestations of the same mucosal inflammation.



As a whole, sinusitis in asthmatics tends to be more severe and resistant to medical treatment. A new study set out to the incidence of specific rhinosinusitis symptoms in asthmatics versus non-asthmatics. This entailed identifying the differences in sinusitis symptoms experienced by asthmatics versus non-asthmatics, evaluating the failure of prescription medications for treatment, and specifying and comparing the surgical treatment need.

The authors of “The Incidence and the Effect of Asthma on Consecutive Patients with Chronic Rhinosinusitis,” are Melanie W. Seybt MD, Kevin C. McMains MD, and Stilianos E. Kountakis MD PhD, all with the Department of Otolaryngology-Head and Neck Surgery, Medical College of Georgia, Augusta, GA. Their findings are being presented at the American Academy of Otolaryngology-Head and Neck Surgery Foundation Annual Meeting & OTO EXPO, being held September 19-22, 2004, at the Jacob K. Javits Convention Center, New York City, NY.


Methodology: A retrospective chart review of 145 adult patients diagnosed with sinusitis at the Medical College of Georgia Rhinology Clinic between January of 2003 and September of 2003 was performed. Data included patient age, gender, presence or absence of asthma, presence of signs and symptoms including allergic rhinitis, nasal polyposis, nasal congestion, headache/facial pain, anosmia/hyposmia, rhinorrhea, and postnasal drip. Other variables evaluated included failure of medical management (prescription drugs) and need for surgical treatment. Patients were designated as asthmatic or non-asthmatic by patient history, use of asthma medications or prior pulmonary function tests.

All patients underwent medical therapy including intranasal steroids, saline nasal spray and irrigations, high-dose guaifenesin and appropriate antibiotic therapy when indicated, before being considered for surgery.

Results: Of the 145 diagnosed with sinusitis, 64 were male, 81 were female. Their ages ranged from 18 to 83 years with a mean of 46.1. Thirty-four patients (23.4 percent) were concurrently treated for asthma while 111 (76.6 percent) were non-asthmatics. Key findings included:

Patients with asthma had a higher incidence of nasal polyps (47 percent vs. 22 percent), olfactory dysfunction (26 percent vs. six percent), and nasal congestion (85 percent vs. 60 percent) compared to patients without asthma.

Non-asthmatics had a higher incidence of headache (72 percent vs. 53 percent) and nasal discharge (58 percent vs. 38 percent) compared to patients with asthma. The incidence of post-nasal drip was similar between the two groups (29 percent for asthmatics and 31 percent for patients without asthma). The incidence of environmental allergies was similar between the two groups based on patient history, medications, and physical examination.

A higher proportion of patients with asthma required primary sinus surgery compared to that of patients without asthma (76 percent vs. 64 percent). Patients with asthma required additional sinus surgical procedures compared to patients without asthma.

Conclusion: In this study, one quarter of our consecutive patients treated for chronic rhinosinusitis at a research facility were diagnosed and actively treated for asthma. Patients with asthma have a higher incidence of nasal polyposis, nasal congestion, and olfactory disturbances. Asthmatic patients also fail primary sinus surgery more frequently and require revision surgery. The exact reason for this higher frequency of failure remains unknown, but evidence suggests a common abnormality in the respiratory epithelium [define] of the upper and lower airway in these patients. On the other hand, patients without asthma typically report a higher incidence of headache and nasal discharge. The researchers suggest that despite the often-challenging course of sinusitis in asthmatics, patients can have dramatic subjective improvement in symptoms when a full range of medical and surgical options are utilized.

| newswise
Further information:
http://www.entnet.org

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>