Research funded by the Christopher Reeve Paralysis Foundation focuses on 108 genes
The study, involving the seven Consortium laboratories, characterized the changes in gene expression at the site of, as well as above and below, a moderate contusion injury in rats. The project involved 108 GeneChips and looked at four time points, spanning from three hours after injury to a more "chronic" state 35 days later. The data analysis produced a spatial and temporal profile of spinal cord injury and also identified several promising avenues for new clinical treatments. The study, the largest of its kind published to-date in the spinal cord field, is now available in the October issue of Experimental Neurology at http://dx.doi.org/10.1016/j.expneurol.2004.05.042.
The CRPF Research Consortium on Spinal Cord Injury is an international network of neuroscientists focused on repair and recovery of function in the chronically injured spinal cord. Through collaborative research, Consortium investigators are studying how to optimize the intrinsic capacity of the adult nervous system to repair and remodel itself as well as how to elicit robust regenerative responses after injury.
Maggie Goldberg | EurekAlert!
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