Researchers at the Georgia Institute of Technology have developed a material that may one day allow patients to forgo daily injections and pills and receive prescriptions instead through micro-thin implantable films that release medication according to changes in temperature. The research, detailing results from testing insulin release in the lab, appears in the September 13 edition of the journal, Biomacromolecules.
Fluorescently tagged insulin occupies a three-layer microgel thin film
“We loaded insulin in layers of microgel films in the lab and released bursts of insulin by applying heat to the films. They were extremely stable and could continue to release the drug for more than one month at a time,” said L. Andrew Lyon, associate professor at Georgia Tech’s School of Chemistry and Biochemistry.
The results add to a decade’s worth of work in controlled and targeted drug delivery. Lyon’s usage of using films assembled from microparticles allows more control over drug release than films previously made in monolithic form.
David Terraso | EurekAlert!
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