Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Heat-controlled Drug Implants Offer Hope for Future

14.09.2004


Researchers at the Georgia Institute of Technology have developed a material that may one day allow patients to forgo daily injections and pills and receive prescriptions instead through micro-thin implantable films that release medication according to changes in temperature. The research, detailing results from testing insulin release in the lab, appears in the September 13 edition of the journal, Biomacromolecules.


Fluorescently tagged insulin occupies a three-layer microgel thin film



“We loaded insulin in layers of microgel films in the lab and released bursts of insulin by applying heat to the films. They were extremely stable and could continue to release the drug for more than one month at a time,” said L. Andrew Lyon, associate professor at Georgia Tech’s School of Chemistry and Biochemistry.

The results add to a decade’s worth of work in controlled and targeted drug delivery. Lyon’s usage of using films assembled from microparticles allows more control over drug release than films previously made in monolithic form.


The insulin tests, said Lyon, serve as proof of a concept that this method of drug delivery is worth further investigation. Currently, the films release their cargo at 31 C, six degrees below human body temperature, but Lyon’s group is working on pushing the release point to a temperature slightly above that of the human body. Once implanted, the pharmaceutical-loaded films could be placed on chips with resistive heaters and scheduled to release drugs according to a time schedule or another trigger.

“One potential use is tying the implant to a blood glucose monitor using radio frequency (RF) technology,” said Lyon. “When the monitor detects that a diabetic patients has low blood sugar, it could send a signal to the chip to heat the film and release insulin into the bloodstream.”

Patients undergoing hormone therapy, chemotherapy or other treatments requiring periodic medication could conceivably get their dosages this way.

“Of course using these films to deliver medications in humans would require many more trials, said Lyon. “We believe we’ve taken an important step in new methods of drug delivery.”

David Terraso | EurekAlert!
Further information:
http://www.gatech.edu

More articles from Health and Medicine:

nachricht 3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg

nachricht Better equipped in the fight against lung cancer
16.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

Im Focus: Computer-Designed Customized Regenerative Heart Valves

Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.

Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...

Im Focus: Light-induced superconductivity under high pressure

A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.

Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Supersonic waves may help electronics beat the heat

18.05.2018 | Power and Electrical Engineering

Keeping a Close Eye on Ice Loss

18.05.2018 | Information Technology

CrowdWater: An App for Flood Research

18.05.2018 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>