Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


New test for kidney disease could reduce dialysis need


A new non-invasive test for kidney disease, developed by clinicians at Hammersmith Hospitals NHS Trust and Imperial College London, is providing a simple, safe, cheap and reliable method of detecting kidney disease. The new test, reported today in the journal Nephrology Dialysis Transplantation, can detect disease before symptoms become apparent, and offers a quicker way of finding out if patients are responding to treatment – which could mean that some patients might not need costly dialysis.

Around 100,000 people in the UK have kidney disease, and the number is increasing, costing the NHS over £2 billion annually. Over 7000 people die from kidney failure every year. “Patients with a progressive kidney disease due to vasculitis* often develop kidney failure, the only treatment for which is dialysis or kidney transplant,” explains Dr Fred Tam, consultant nephrologist at Charing Cross and Hammersmith Hospitals and senior lecturer at Imperial College London. “By looking at a chemical produced when the kidney becomes inflamed, we can test patient’s urine for the level of disease, often before clinical symptoms appear.” The test could eventually replace the need to take biopsies from the kidney – a complicated and uncomfortable surgical procedure.

Current treatments for kidney vasculitis involve using drugs that knock out the body’s immune system. These drugs can cause side effects, including vulnerability to infection and risk of reduced fertility. This new test can accurately measure response to treatment, allowing clinicians to tailor treatments to individual patients. “The test can tell us if a treatment is working, and shows us, before it is too late, if we need to change the medication, without the need to perform a biopsy,” adds Dr Tam.

The test works by identifying the amount of a cytokine molecule called monocyte chemoattractant protein-1 (MCP-1) present in the urine. MCP-1 is produced by the body as a response to inflammation, and attracts white blood cells to the area to combat pathogens. However, overreaction of the white blood cells may also cause vasculitis and organ damage. Each test costs less than £20 to administer. Kidney dialysis costs around £29,000 per year for one patient.

Case study

Mr Noureddine Khallouki from North London was admitted to Hammersmith hospital earlier this year suffering from renal vasculitis, and volunteered to take part in trialling the MCP-1 test. “I was happy to help out, as I think it’s important to give something back. Any new developments that reduce the need to take biopsies is a good thing – the procedure is uncomfortable and meant I was unable to move for about 8 hours afterwards in case of bleeding.” The test showed that Mr Khallouki was responding well to treatment and he has since made a full recovery.

Simon Wilde | alfa
Further information:

More articles from Health and Medicine:

nachricht NIH scientists describe potential antibody treatment for multidrug-resistant K. pneumoniae
14.03.2018 | NIH/National Institute of Allergy and Infectious Diseases

nachricht Researchers identify key step in viral replication
13.03.2018 | University of Pittsburgh Schools of the Health Sciences

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Locomotion control with photopigments

Researchers from Göttingen University discover additional function of opsins

Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...

Im Focus: Surveying the Arctic: Tracking down carbon particles

Researchers embark on aerial campaign over Northeast Greenland

On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...

Im Focus: Unique Insights into the Antarctic Ice Shelf System

Data collected on ocean-ice interactions in the little-researched regions of the far south

The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...

Im Focus: ILA 2018: Laser alternative to hexavalent chromium coating

At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.

When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...

Im Focus: Radar for navigation support from autonomous flying drones

At the ILA Berlin, hall 4, booth 202, Fraunhofer FHR will present two radar sensors for navigation support of drones. The sensors are valuable components in the implementation of autonomous flying drones: they function as obstacle detectors to prevent collisions. Radar sensors also operate reliably in restricted visibility, e.g. in foggy or dusty conditions. Due to their ability to measure distances with high precision, the radar sensors can also be used as altimeters when other sources of information such as barometers or GPS are not available or cannot operate optimally.

Drones play an increasingly important role in the area of logistics and services. Well-known logistic companies place great hope in these compact, aerial...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

Ultrafast Wireless and Chip Design at the DATE Conference in Dresden

16.03.2018 | Event News

International Tinnitus Conference of the Tinnitus Research Initiative in Regensburg

13.03.2018 | Event News

International Virtual Reality Conference “IEEE VR 2018” comes to Reutlingen, Germany

08.03.2018 | Event News

Latest News

Wandering greenhouse gas

16.03.2018 | Earth Sciences

'Frequency combs' ID chemicals within the mid-infrared spectral region

16.03.2018 | Physics and Astronomy

Biologists unravel another mystery of what makes DNA go 'loopy'

16.03.2018 | Life Sciences

Science & Research
Overview of more VideoLinks >>>