Pushing neurons’ physiological limits provides researchers with new ways to repair nerve damage
Sometimes it is the extremes that point the way forward. Researchers at the University of Pennsylvania School of Medicine have induced nerve fibers – or axons – to grow at rates and lengths far exceeding what has been previously observed. To mimic extreme examples in nature and learn more about neuronal physiology, they have mechanically stretched axons at rates of eight millimeters per day, reaching lengths of up to ten centimeters without breaking. This new work has implications for spinal cord and nerve-damage therapy, since longer implantable axons are necessary for this type of repair.
In the present study, the team, led by Douglas H. Smith, MD, Professor of Neurosurgery and Director of the Center for Brain Injury and Repair, placed neurons from rat dorsal root ganglia (clusters of nerves just outside the spinal cord) on nutrient- filled plastic plates. Axons sprouted from the neurons on each plate and connected with neurons on the other plate. The plates were then slowly pulled apart over a series of days, aided by a precise computer-controlled motor system. "By rapid and continuous stretching, we end up with huge bundles of axons that are visible to the eye," says Smith. The axons started at an invisible 100 microns and have been stretched to 10 centimeters in less than two weeks. Smith and colleagues report their findings in the cover story of the September 8, 2004 issue of the Journal of Neuroscience.
Karen Kreeger | EurekAlert!
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Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
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Water molecules exist in two different forms with almost identical physical properties. For the first time, researchers have succeeded in separating the two forms to show that they can exhibit different chemical reactivities. These results were reported by researchers from the University of Basel and their colleagues in Hamburg in the scientific journal Nature Communications.
From a chemical perspective, water is a molecule in which a single oxygen atom is linked to two hydrogen atoms. It is less well known that water exists in two...
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