A tiny capsule containing tissue that secretes a cocktail of brain-nourishing neurotrophic factors may one day help reduce the damage and disability of stroke, according to research published in the September issue of Stroke.
Choroid plexus tissue has innate roles in developing and protecting the brain and when additional tissue is transplanted into an animal model of stroke, it reduces stroke size by about 65 percent, Medical College of Georgia researchers report. "What we have seen is the reduction of the size of the stroke in the brain, and the animals that received the transplant showed functional recovery in motor as well as neurological function," said Dr. Cesario V. Borlongan, MCG neuroscientist and first author on the paper.
The study is an important step in moving the potential treatment to clinical trials because the porcine choroid plexus tissue also could be used in humans, Dr. Borlongan said. The cells of the pig choroid plexus are similar in size and function to human cells and pig brain tissue has been used in humans to treat Parkinsons disease.
Toni Baker | EurekAlert!
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