Myocardial infarction, caused by coronary artery occlusion, can lead up to loss of muscle tissue of the heart and functional detriment, even at times where rapid reperfusion strategies like PTCA or thrombolysis are at hand. In the study presented here, we investigated embryonic endothelial progenitor cells as therapy for ischemia reperfusion injury in a large animal model (pig). This model, which induces an infarct of predictable size in a pig heart, was used to test the cardioprotective potential of the embryonic cells, since adult endothelial progenitor cells (EPCs) have been used in similar models with success and are utilized in ongoing patient studies.
Endothelial progenitor cells are cells which are able to differentiate into endothelial cells and replace the inner vascular wall.In this study, we used 5x106 embryonic endothelial progenitor cells, a number relatively modest with respect to the size of the targeted infarct region. To compensate for this modest cell number, we used a regional delivery system, called retroinfusion, which infuses the cells through the vein draining the infarct region. (Previous studies had shown a substantial increase of efficacy using this application mode).
We now found that indeed retroinfusion of 5x106 embryonic EPCs sufficed to reduce infarct size and improve regional myocardial function in the ischemic area. Interestingly, systemic application of the same number of cells had no significant effect, indicating the relevance of the regional application. The superiority of the regional delivery was confirmed in tests using radioactively labeled cells, where retroinfusion yielded a sixfold higher amount of recruited cells in the heart than systemic application.
Camilla Dormer | alfa
A promising target for kidney fibrosis
21.04.2017 | Brigham and Women's Hospital
Stem cell transplants: activating signal paths may protect from graft-versus-host disease
20.04.2017 | Technische Universität München
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
Two researchers at Heidelberg University have developed a model system that enables a better understanding of the processes in a quantum-physical experiment...
Glaciers might seem rather inhospitable environments. However, they are home to a diverse and vibrant microbial community. It’s becoming increasingly clear that they play a bigger role in the carbon cycle than previously thought.
A new study, now published in the journal Nature Geoscience, shows how microbial communities in melting glaciers contribute to the Earth’s carbon cycle, a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
21.04.2017 | Physics and Astronomy
21.04.2017 | Health and Medicine
21.04.2017 | Physics and Astronomy