The origins of rheumatoid arthritis (RA) have been studied with the help of data generated from close to 2000 patients with recent onset RA, who have been followed longitudinally be means of structured surveillance programs in Swedish Rheumatology and coordinated from the Karolinska Institutet and Karolinska University Hospital.
"One interesting finding is that smoking in the context of certain genetic predispositions, increases the risk for rheumatoid arthritis in a dramatic way, i.e. a marked gene-environment interaction is present between genes and environment in RA. The findings reinforce the special need for programs aimed at cessation of smoking in individuals with RA and at risk for RA" says Lars Klareskog, Professor at Karolinska Institutet.
The outcomes of RA, and in particular the results of different treatments have also been studied with the help of longitudinal structured surveillance programs. "Here, we have been able to monitor both effects and adverse effects of conventional as well as novel "biological" therapies against RA in clinical practice. The systems have enabled us to study the prognostic value of immunologic as well as genetic factors, and thereby helped in optimising therapy for the individual patient" says Lars Klareskog.
Pontus Bråmer | alfa
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